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Zylo Therapeutics
An SI Board Since January 2018
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Emcee:  donpat Type:  Moderated
Zylö Therapeutics

Father and son doctors Friedman using nano to speed healing.

zylotherapeutics.com

OVERVIEW

Zylö Therapeutics has an innovative sustained-release drug-delivery system that was developed by Joel Friedman MD PhD and Adam Friedman MD FAAD. The delivery system uses patented hydrogel-derived nanoparticles, called Nanopods™, to deliver—in a sustained and controlled manner—notoriously hard-to-deliver therapeutic agents through topical administration.

It took more than 10 years and $10 million to develop the Nanopod™ delivery system. The second generation of the technology improved considerably on the first, reaching a key milestone of 24+ hours of sustainable delivery, thereby allowing for once-a-day application.

Notably, the Nanopod™ delivery system has harnessed the therapeutic potential of:

1. Nitric Oxide (NO), one of the most notable and versatile, yet elusive (it’s an unstable gas), biomolecules produced by practically every cell in our bodies, with the following mechanisms of action:
a. vasodilatory (enhanced blood flow), e.g., Viagra serves to increase NO production
b. anti-inflammatory
c. anti-microbial (it effectively kills gram-positive and gram-negative pathogens….and MRSA as well)
d. anti-oxidant
e. scar minimizing

2. Curcumin (diferuloylmethane), a natural polyphenol/antioxidant with an extensive body of mechanistic and clinical data, but plagued by poor bioavailability (the kidneys break down the curcumin within minutes) and by the persistent yellow stain it leaves behind. It is profoundly anti-inflammatory, among other properties.

3. Cannabinoids, which have a myriad of possible therapeutic applications, but the current modes of delivery have certain limitations that are overcome by the Nanopod™ sustained delivery system.

4. Vitamin A, which is known to enhance skin elasticity, but the night creams that contain Vitamin A will enrich one’s skin for 10-20 minutes. Contrast that with a vitamin A-loaded Nanopod™ cream, which will nourish the skin, when applied nightly, 24x7.

5. Quercetin, Vitamin C, Vitamin E, melanin, allicin (garlic oil), which are all similar to Vitamin A….sustained delivery is far better and will have clear-cut benefits over tablets or creams that provide a short-lived dose of the therapeutic agent.

6. Sildenafil and similar erectile dysfunction therapeutics, which, when taken in tablet form, enhance the production of Nitric Oxide…systemically. This creates certain systemic side effects, such as nitrite headaches, dyspepsia, blurred vision. Further, men with certain cardiovascular irregularities should not risk taking these drugs. In all, it is believed that 30-40% of men with ED are affected by these systemic effects. Topically applied sildenafil-loaded or NO-loaded Nanopods™ would provide enhanced blood flow locally (where it’s needed) and would avoid the systemic side effects.

7. Proprietary payloads that have been shelved by pharmaceutical firms due to a lack of sustainable action. We believe there are dozens, if not hundreds, of such payloads that would be an ideal fit with our Nanopod™ platform technology. Most any water- or fat-soluble molecule can be loaded into our Nanopods™.

The patented Nanopod™ delivery system also addresses the constraints of other established and emerging therapeutic ingredients.

No public stock trading....yet.

I think it has a tremendous future!

With NanoViricides/NNVC, another nano blockbuster in training?????
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ReplyMessage PreviewFromRecsPosted
19NO as an antiviral: Critical Role in Viral Infections? Carol Shoshkes Reiss* adonpat-March 25
18Study reveals new mechanism used by cancer cells to disarm attacking immune celldonpat-February 27
17Company co-founded by Nobel Prize winner launches nanotechnology-based cosmeticsdonpat-February 4
16Very impressive: EXECUTIVE TEAM Scott R. Pancoast, CEO (and Company Founder andonpat-February 3
15Quantity matters to some; quality matters to me. Some even use multitudes of aldonpat-February 2
14Wow. Two posters on this board. I see there are no bans - until now. Ha!Its_lose_not_loose-February 2
13Size isn't everything...:>) Sorry, couldn't resistSavant-February 2
12Erectile Dysfunction Drugs Market Size Will Be Worth $3.2 Billion By 2022: Granddonpat-February 2
11I'm enthralled with the possibilities: 1. A composition for releasing nitridonpat-February 1
10Zylo and Novan both use nitric oxide but Zylo has a sustained release feature todonpat-February 1
9I would like to see Novan and Zylo differentiated!donpat-January 31
8Why Novan Inc. Is Imploding Today Jan. 27, 2017 Brian Feroldi Shares collapsedonpat-January 31
7Is Nitric Oxide a Revolution In Acne Treatment? August 16, 2015 Say the wordsdonpat-January 31
6Novan - another nitric oxide centered company: investors.novan.com Stock Infordonpat-January 31
5Nitric oxide CHEMICAL COMPOUND WRITTEN BY: The Editors of Encyclopædia Bdonpat-January 31
4What is nitric oxide and how does it work? Its impact on bodybuilders, heart hedonpat-January 31
3Nitric oxide ( nitrogen oxide[3] or nitrogen monoxide), a chemical compound, isdonpat-January 31
2SC: Zylö Therapeutics to Locate New Operations in Greenville County, Createdonpat-January 31
1No public trading, no stock symbol. Zylo Therapeutics Greenville startup develdonpat-January 29
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