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Biotech / Medical
MultiCell Technologies, Inc.
An SI Board Since July 2004
Posts SubjectMarks Bans Symbol
228 16 0 MCET
Emcee:  CENTrader Type:  Moderated
MultiCell Technologies Inc.(OTCBB:MCET), with guidance by exceptional management & brilliant scientists, is poised to grow with the exploding human cell-based in-vitro testing industry. With the cost of development for the average drug now estimated at over $800,000,000, pharmaceutical companies desperately need to improve their efficiency when it comes to weeding out new molecular entities that could pose problems in later stage development.

To this end, most are investing in more early stage high-throughput in-vitro testing with human cells (where possible).

Since the majority of drugs now on the market are metabolized in the liver - over half of them by one hepatic enzyme alone - hepatocytes are among the most prized cells for early toxicological screening, drug development, and drug-to-drug interaction studies.

The following is a list of companies who have signed or are preparing to sign licenses to evaluate MultiCell's unique line of readily available, fully functional, immortalized hepatocytes:

Astra Zeneca, Aventis, Amgen, Bristol Myers Squibb, Eisai, Lilly, Novartis, Abbott, Bayer, Boehringer Ingleheim, Biogen, Genzyme, Glaxo Smith Kline, Johnson & Johnson, Hoffman LaRoche, Lexicon, Merck, Millenium, Neurogen, Shering Plough, Pfizer, Hoffman La Roche, Wyeth, Daiichi, Takeda (Japan’s largest pharma), Fujisawa, Ono, Mitsubishi, Shinogi, Sumitomo, Japan Tobacco

MultiCell has developed a unique line of liver cells that reproduce endlessly in culture. This cell line, designated as Fa2N-4, could replace primary human liver cells (from cadavers) for use in several types of high throughput early tox screening, enzyme induction, and drug/drug interaction studies.

Primary liver cells are difficult to obtain, not available on any predicable schedule, expensive and labor intensive to prepare, and of inconsistent quality. Also, primaries lose their functionality rapidly when thawed following cryopreservation. MultiCell's immortalized hepatocytes do not have any of these limitations.

Previous attempts to create immortalized liver cell lines employed tumorigenic cells which were incapable of generating the necessary P450 enzymes. MultiCell's lines are immortalized using the large SV40 T-antigen in a process that ultimately results in the expression of hTERT, allowing the cells to reproduce indefinitely, yet maintain the enzyme expression profiles of a fully differentiated liver cell.

From a recent study done by Hoffman La Roche, which expanded on similar findings made by Pfizer:

“Conclusion: Fa2N-4 cells performed much like fresh human hepatocytes. Using a panel of inducers, both mRNAs and P450 enzymatic activities were induced. These immortalized cells have potential for use as an alternative to primary human liver tissue for In Vitro Induction Studies.”

MultiCell has signed a seven-year, $18,000,000 exclusive distribution deal with XenoTech LLC, a leading cell product provider, and one of the United States' most successful CRO's.

In addition, MultiCell's hepatocytes produce fully human, therapeutic proteins including albumin, and factors VIII and IX. And chief scientist Dr. Ronald Faris has generated a unique protein, dubbed the "Magic-X Protein," from the cells for which a patent application will soon be made. This protein may treat a currently untreatable acute disease with an estimated $1,000,000,000 annual market. Details will not be released until the patent application has been submitted.

MultiCell's hepatocytes also generate adult liver stem cells, for which Dr. Faris own's the patent. Both the hepatocytes themselves and the stem cells could be used in allogeneic transplants to treat various types of liver disease.

Adult liver stem cells also make ideal vectors for gene therapy directed at the human liver.

Finally, immortalized hepatocytes represent the only commercially practical method of supplying cells for a bioartificial liver, and several of these are in or near clinical trials. However, MultiCell's subsidiary, Xenogenics, owns the PREMIER bioartificial liver technology in the industry. Patented under the name "SYBIOL," which stands for Synthetic Bioartificial Liver, the continuing R&D of this medical device is currently on hold, allowing the parent, MultiCell, to focus on the manufacturing, promotion & marketing of it's liver cell lines to "BigPharma." As the FDA approval process is a long & expensive one, CEO Jerry Newmin has chosen to defer the SYBIOL project at the present time, in favor of redirecting The Company's focus & resources towards cell-based products to attempt to bring about immediate revenue & profits. To this end, it is The Company's hope of increasing shareholder value in the near term.

MultiCell was formally Exten Industries - a holding company. The company underwent a radical restructuring, purchased and then merged with MultiCell, and is now on its way to becoming a profitable biotech in the field of cell-based products and cell-based therapy.

(Special thanks to "ThalioMiles" of Raging Bull for composing much of this MultiCell Synopsis)

Wishing "Profound Prosperity" to all present & future MultiCell investors!

Long & Strong...I Remain,

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228MultiCell Technologies Files Patent Application Covering New Class of RNA Therapjimpit-1/15/2014
227MultiCell Technologies To Announce Positive Preclinical Results at 2012 ASCB Meejimpit-9/27/2012
226MultiCell Technologies Updates Preclinical Results for MCT-465 and MCT-485 in Prjimpit-8/10/2012 Coverage on MultiCell Technologies, Inc. (OTCBB: MCET) and Otjimpit-5/17/2012
224MultiCell Technologies Announces Positive Preclinical Results for MCT-465 and MCjimpit-5/16/2012
223Xenogenics Received Rights to Polyanhydride Compounds Drug Delivery Patent Xenojimpit-2/16/2012
222MultiCell Technologies Receives Final Payment Under QTDP Program MultiCell Techjimpit-1/3/2012
221MultiCell Technology and Aastrom Biosciences Aim to Shatter Stem Cell Myths Mujimpit-8/5/2011 Item 1.01 <b>Entry Into a Material Definitive Shawn Donahue-7/11/2011
219MultiCell and University Health Network Will Evaluate Two Potential Therapies fojimpit-7/11/2011
218Hope so! Some of us have been patiently waiting for years! GLTA, Jimjimpit-6/8/2011
217<b>MCET</b>..Showed very strong support above the .01 area. We shounocpimping-6/6/2011
216Insight on MultiCell Technologies, Inc. and Aradigm Corporation <b>New Dejimpit-6/2/2011
215MultiCell Technologies Headlines as Stock in Focus on <jimpit-6/1/2011
214MultiCell Technologies is Granted Stem Cell Patent...! <b>MultiCell Technjimpit-5/31/2011
213<b>The New York Times</b> Sunday, April 3, 2011 Business > Compajimpit-4/3/2011
212Xenogenics Corporation Retains the Emmes Group to Advise on Fund Raising Effortsjimpit-2/23/2011
211MCET Mentioned in this article... <b>Abbott Labs’ bioresorbable stent appjimpit-1/11/2011
210MCET Receives $733,437... <b>MultiCell Technologies Receives $733,437 Casjimpit-11/2/2010
209<b>MultiCell's Majority Owned Subsidiary Acquires Bioabsorbable Intervjimpit-10/19/2010
208"...Do you have ideas of anyone else currently doing this?..." No...ujimpit-9/2/2010
207Thank you for the links Jim! Interesting and potentially valuable information giShawn Donahue-9/2/2010
206No problem Shawn...glad to help when I can. No I didn't get to hear the CC.jimpit-8/31/2010
205Thanks Jimpit for your last 3 updates for MCET. Even though I don't own muchShawn Donahue-8/30/2010
204NEWS...MCET Applies for Project Grants... <b>MultiCell Technologies Applijimpit-8/2/2010
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