Discussion and file folder for RNAi stuff. I know of only one company that is a public, pure play, and will attach an unmanaged portfolio. That company is RNAI, the revamped RZYM. Another player is QGENF, but it is hardly pure. Private companies include suppliers Imgenex, Ambion, Novagen, and Dharmacon, as well as therapeutic competitor to RNAI, Anlynam. 2010 Update: more public companies are around: a few are mentioned on SI but don't have threads: Silence Therapeutics (SLN.L), Tekmira (TKM.TO), RXi (RXII), Rosetta Genomics (ROSG) (more of a diagnostics play, I thought), Benitec (BLT.AX), & Targeted Genetics (TGEN). Some of the foreign companies have American listings on the pink sheets, but I doubt they trade much, so caveat emptor.
Here are some important general articles relating to siRNA and delivery issues. All are free and full text!
RNA interference is mediated by 21- and 22-nucleotide RNAs
Small Interfering RNAs: A Revolutionary Tool for the Analysis of Gene Function and Gene Therapy
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
Retroviral delivery of small interfering RNA into primary cells
Links to company specific threads (pure plays only):
Sirna: Subject 10854
Alnylam (now publlic): Subject 54862
Link to blog on RNAi therapeutics: