| To: bmaz001 who wrote (674) | 2/6/2023 12:25:07 PM | | From: Area51 | | | | Thanks! Great list. When I did sort the list (by an estimate of cash/ market-cap) I think IMAB and GRCL (Chinese listed) came out on top. But likely in error, as IMAB had 574 million in cash in USD as of last report so highly unlikely that their EV is negative 3400 million as the spreadsheet lists (They do have about 3900 million cash in RMB so maybe that is what the spreadsheet is pulling in for cash?). I still bought a (very) little IMAB today as it fell to the $5 area.
top of sorted list based on early january market cap:
| Ticker | Country | Market Cap (M) | EV | Cash (Est) | Short % of Float | Cash (% of MC) | | GRCL | China | 150.3 | -1275.6 | 1425.9 | | 949% | | IMAB | China | 442.9 | -3375.3 | 3818.2 | | 862% | | NEXI | United States | 9.4 | -35.3 | 44.7 | 1.80% | 476% | | SGTX | United States | 11.7 | -36 | 47.7 | 0.80% | 408% | | NXTC | United States | 44.2 | -125.1 | 169.3 | 1.50% | 383% | | TALS | United States | 50.5 | -140.3 | 190.8 | 3.70% | 378% | | ELEV | United States | 21.2 | -57.4 | 78.6 | 0.30% | 371% | | ENVB | United States | 5.8 | -15.3 | 21.1 | 2.20% | 364% | | AMPE | United States | 4.5 | -11.7 | 16.2 | 1.50% | 360% | | PYXS | United States | 51.2 | -131.2 | 182.4 | 1.80% | 356% | | ACHL | United Kingdom | 48.7 | -122.2 | 170.9 | | 351% | | LMNL | Canada | 11.3 | -27.9 | 39.2 | 0.10% | 347% | | SLRX | United States | 5 | -11.9 | 16.9 | 1.60% | 338% | | BLCM | United States | 8.5 | -20.2 | 28.7 | 1.40% | 338% | | SRZN | United States | 21.5 | -50.8 | 72.3 | 0.60% | 336% | | SNPX | United States | 7.9 | -18.5 | 26.4 | 6.20% | 334% | | CELZ | United States | 6.6 | -15.4 | 22 | 1.40% | 333% | | MGTA | United States | 30.3 | -67.2 | 97.5 | 10.20% | 322% | | TCRX | United States | 32.9 | -70.5 | 103.4 | 0.90% | 314% | | MEIP | United States | 40 | -84.7 | 124.7 | 2.60% | 312% | | AEZS | United States | 17.4 | -36.3 | 53.7 | 2.00% | 309% | | AVRO | United States | 37.8 | -78.2 | 116 | 0.60% | 307% | |
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| To: Area51 who wrote (677) | 10/23/2023 7:45:52 PM | | From: JamesK | | | | | One that makes your list due to its decline is KOD. Has like cash 4 times market cap. Market cap used to be $8 Billion. Has to be one of the worst biotech implosions. |
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| From: JamesK | 10/28/2023 3:59:18 PM | | | | | | | FATE is another one that experienced a large loss after attaining a huge market cap. Serious wealth destruction. Cash is more than twice it's current market cap. |
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| To: JamesK who wrote (679) | 10/29/2023 6:01:50 PM | | From: A.J. Mullen | | | | Fate is interesting. I was tempted before the sell-off. It’s working on exciting stuff – off-the-shelf immunotherapies. At the beginning of the year, it chose to end rather than revise a collaboration with J&J which resulted in a termination fee to Fate of over $50m. They also announced a 50% reduction in headcount. It said it aimed to have a runway through 2025. Its cash is now approximately twice its current free-cash flow (including the termination fee).
Ashley |
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| To: A.J. Mullen who wrote (680) | 10/30/2023 6:31:52 PM | | From: JamesK | | | | They are all so beaten down. I'm sure in five years they'll be so many, "I should have bought that one".
There are so many of these cell therapy companies, having a hard time knowing which to pick. They are starting to show some promise in treating autoimmune diseases with CAR-T. |
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| From: scaram(o)uche | 4/3/2024 2:25:58 PM | | | | | | We usually look for negative EVs after a prolonged sector drought. But we've had good sector performance since November, with exception of a recent rough spot.
Matt Gamber at Twitter has looked for negative EVs under these circumstances.....
twitter.com
(thread)
Of those issues he mentions, I took a position in CMRX. Yeah, the same CMRX that brought such CMV-related misery to investors.
ONC201 for recurrent H3 K27M-mutant high-grade glioma, a molecule derived from the Oncoceutics munch. Observed toxicity in trials to date, but nothing that has derailed it.
https://aacrjournals.org/cancerdiscovery/article/13/11/2370/729854/Clinical-Efficacy-of-ONC201-in-H3K27M-Mutant
This position was taken without knowledge of market size, the difficulty penetrating it, or competitors addressing it. |
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| From: JamesK | 4/7/2025 5:49:19 PM | | | | | | | EDIT is certainly below cash value. Feels like the worst biotech bear ever. Almost all down since 2021. Did start to do better in the fall. Then the election happened. |
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