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   Biotech / MedicalGMED - GenoMed Inc.


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From: Tadsamillionaire12/20/2006 12:19:34 PM
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ACP Observer Publishes Letter on GenoMed's Ability to Prevent Most Kidney Failure
GenoMed(TM) (Pink Sheets:GMED), a Next Generation Disease Management company, announced today that ACP Observer, the monthly news magazine for doctors of internal medicine published by the American College of Physicians, included a letter in its December issue referring to GenoMed's ability to prevent potentially most kidney failure in the US.

The letter, entitled "Promoting Dialysis Alternative" (http://www.acponline.org/journals/news/dec06/letters.htm), was written by GenoMed's CEO, Dr. David Moskowitz, who is a Fellow of the American College of Physicians. The letter calls the medical community to task for the four years of "organizational silence" since Dr. Moskowitz's paper on kidney failure was first published in a peer-reviewed medical journal.

Dr. Moskowitz's paper, published in 2002, described a novel treatment approach using already existing medications but at a higher dose. If begun early enough, this approach could reverse kidney failure in white and black patients with diabetes and high blood pressure. These two diseases cause 90% of kidney failure in the US.

The Centers for Medicaid and Medicare (CMS) currently pay about $25 billion annually for kidney dialysis and transplantation. When Dr. Moskowitz briefed CMS about his paper in 2004, the Medical Director and his staff at CMS referred Dr. Moskowitz to the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (NIH). Neither the NIDDK, CMS, nor any non-profit kidney association had any interest.

Publication of Dr. Moskowitz's letter in ACP Observer is the first time that a mainstream medical news magazine has carried the story.

Said Dr. Moskowitz, "In medical school, we were encouraged to find cures. I wouldn't have believed it if somebody had told me then that there was no point in finding any cures because news of the cure would just be suppressed. Yet that is exactly what has happened for the past four years."

Dr. Moskowitz continued, "Medicine, like any human endeavor, thrives on the status quo, and hates change. In the 1950s, nobody thought twice about putting polio wards and TB sanitaria out of business. But potentially eliminating 90% of a $25 billion a year industry is another thing altogether. Nowadays, nobody wants their budget cut."

Added Dr. Moskowitz, "The American College of Physicians has long been the most prestigious organization in the United States for internists. I've always been extremely proud to belong to it. I'm especially grateful for its courage in breaking the silence that has surrounded my paper for the past four years."

About GenoMed

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From: Tadsamillionaire1/18/2007 8:06:47 PM
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New Strain of Bird Flu Found in Egypt Is Resistant to Antiviral Drug

A strain of avian flu that is resistant to the antiviral drug oseltamivir has been isolated from two family members in Egypt, the World Health Organization said yesterday.

The development is potentially dangerous because oseltamivir, commonly sold under the name Tamiflu, is the chief weapon against the flu strain, H5N1, which many worry could mutate into a strain that could set off a worldwide pandemic.

The health organization emphasized that it was too early to tell whether the resistant strain had developed independently in the two patients, who were both under treatment with the drug, or whether they had picked it up from birds or from each other. The resistant strain did not spread to anyone else, including a third family member who also had avian flu.

“Given the information we have, we don’t see any broad public health implications,” said Dick Thompson, a spokesman for the organization.

Mr. Thompson was unsure which Egyptian cluster of flu infections the patients were part of. But another source said it was one in Gharbiya Province, roughly 50 miles north of Cairo, in which flu killed three people last month in a 33-member family living in one compound.

Oseltamivir-resistant strains were found in three unrelated patients in Vietnam in 2005 but did not spread.

The development “is not a big surprise, but it certainly is disheartening,” said Dr. Anne Moscona, an expert on flu treatment at Weill Cornell Medical College.

The oseltamivir-resistant strain in Egypt was susceptible to zanamivir, which is sold as Relenza, and to amantadine, which is from an older, cheaper and easier-to-use class of drugs but is not normally used as a first-line treatment because many avian flu strains are resistant to it.

The development, Dr. Moscona said, suggested that doctors might have to consider switching to a cocktail of drugs as first-line treatment, as is done with AIDS medications and sometimes with antibiotics.

Dr. Andrew T. Pavia, chairman of the pandemic influenza task force of the Infectious Diseases Society of America, said it was theoretically possible that resistant strains of the flu had developed simultaneously in two related patients, especially if they were very sick and had been treated with doses of oseltamivir that were too low.

But if one transmitted it to the other, “it would be very worrisome,” he said, because previous resistant strains had been very weak at infecting new victims.

nytimes.com

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From: jmhollen2/12/2007 12:42:17 PM
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"African Gene" Found

Contact: David W. Moskowitz MD
CEO, GenoMed tel. 314.983.9933 dwmoskowitz@genomed.com

ST. LOUIS—February 12, 2007—GenoMed® (OTC Pink Sheets GMED), a Next Generation Disease Management company, announced today that it has found the "African gene," responsible for the much higher incidence of diabetes, high blood pressure, and kidney failure among people of African ancestry than whites.

High blood pressure, and many other diseases, are roughly twice as common among African Americans than whites. For people with high blood pressure, kidney failure is five times more common among African Americans than whites. So blacks have 10 times more kidney failure than whites. The difference has been ascribed to the "African gene."

The "African gene," or more accurately, "African genotype," is actually a misnomer. It is not unique to Africans, but is present in every ethnic group, where it appears to cause most common diseases. (It is just more frequent among Africans). For example, it is associated with three-quarters of common diseases among whites. GenoMed has shown that knowing this "master" disease gene makes it possible to prevent kidney failure in whites, blacks, and Hispanics.

Said Dr. David Moskowitz, GenoMed's CEO, "It is appropriate that this February, Black History Month, we start trying to make kidney dialysis a thing of the past, since African Americans disproportionately make up the rolls of dialysis companies. So do other people of color: Hispanics and Native Americans have much more diabetes and kidney failure than whites."

Dr. Moskowitz continued, "The advantage of knowing the gene behind most common diseases is obvious. In this case, society is fortunate to already have safe, effective, cheap generic drugs that work against the gene. Our only problem for the past five years has been in getting the word out."

Dr. Moskowitz has published extensively on the African gene in peer-reviewed medical journals beginning in 1996.

About GenoMed

GenoMed estimates that it can already save 10% of healthcare costs and extend life by 5 years. Patients are encouraged to contact Dr. Moskowitz (dwmoskowitz@genomed.com) about joining GenoMed's Clinical Outcomes Improvement Program (COIP®).

.

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From: Tadsamillionaire2/13/2007 12:10:17 PM
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Help needed for bird flu vaccine, says official

Alvin Darlanika Soedarjo, The Jakarta Post, Jakarta

Indonesia needs foreign help to develop a bird flu vaccine for humans because local pharmaceutical companies lack the necessary technology, an official said Monday.

"Indonesia, in this case state-owned drugmaker Bio Farma, does not have the technology and expertise to create the vaccine. So far we can only offer foreign pharmaceutical companies our strain of the virus to work on," Health Ministry spokesperson Lily S. Sulistyowati told The Jakarta Post.

Lily said drugmaker Baxter approached Health Minister Siti Fadilah Supari about a year ago and offered to collaborate on a human vaccine using the Indonesian strain of the bird flu virus.

"Other companies came to us with their own vaccines using strains from other countries, such as Vietnam. We insisted that Indonesia needs a vaccine developed from our own strain.

"A vaccine derived from Indonesia's strain of the bird flu virus will be more effective when used here," she said.

Switzerland-based Baxter Healthcare SA, a subsidiary of U.S. pharmaceutical company Baxter International, has signed a memorandum of understanding with the Health Ministry to develop a human vaccine based on the Indonesian strain of the H5N1 virus.

"The vaccine is in the clinical testing phase and projected to be ready for launch in December. However, we could release the product under emergency conditions," she said.

The ministry stopped sending bird flu samples to WHO laboratories after Australian pharmaceutical company CSL announced it was developing, without Jakarta's consent, a vaccine developed from the Indonesian strain of bird flu.

Contacted separately, Indonesia Health Consumer Empowerment Foundation chairman Marius Widjajarta said the Health Ministry was right to stop sending virus samples to overseas labs.

"Indonesia has the right to stop sending out its strain because WHO was trying to develop a vaccine with commercial benefits and Indonesia would not have benefited for its efforts," Marius said.

He said the ministry should launch an investigation into WHO's actions regarding the "leakage" of Indonesian bird flu samples.

"As the hardest hit country (by bird flu), Indonesia should be careful with outside assistance because it could create a dependence on other countries," he added.

Experts still fear the virus could mutate into a more lethal version that would be easily transmitted from human to human, sparking a global pandemic that could kill millions.

thejakartapost.com

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From: Tadsamillionaire3/12/2007 11:39:16 AM
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GenoMed Prevents Sickle Cell Pain for Over a Year
GenoMed (OTC Pink Sheets:GMED), the Next Generation Disease Management company whose business is public health™, announced today publication of a case report of a sickle cell patient whose pain has disappeared for over a year thanks to GenoMed's treatment.

The patient is a middle-aged African American woman who for years required multiple pain pills every day to tolerate the pain of her sickle cell disease. Since beginning GenoMed's trial on Dec. 22, 2005, she experienced no pain until her trial medication accidentally ran out on February 6, 2006. Said her physician, who is lead author on the case report, "Prior to this experiment, for over two years, there has not been more than a day, at least during the winter months, when she has not required some Vicodin."

Her pain ceased within a few days of resuming GenoMed's treatment in February, 2006. In June, 2006, her physician intentionally stopped GenoMed's treatment to see what would happen. The patient's pain recurred within a week. When she resumed GenoMed's treatment, her pain again stopped within a few days. She has been pain-free on GenoMed's treatment for a total of 14 months now.

Said Dr. David Moskowitz, GenoMed's CEO and Chief Medical Officer, "Although only a single patient, she satisfied a rigorous clinical test. As long as the patient was on our treatment, her pain was gone. On two occasions, one accidental and one deliberate, our treatment was stopped. On both occasions her pain recurred promptly, only to disappear quickly after treatment was resumed. She hasn’t needed pain pills in over a year; previously she took an average of four Vicodins a day. It doesn't get much more convincing than this."

Added Dr. Moskowitz, "We'd like to see if our results hold up with additional patients. Until now, there hasn’t been effective treatment for sickle cell disease.”

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To: Tadsamillionaire who wrote (327)3/12/2007 11:40:06 AM
From: Tadsamillionaire
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Good News for World Kidney Day: GenoMed Can Prevent Most Kidney Failure
GenoMed® (Pink Sheets:GMED), a Next Generation Disease Management company, announced today, World Kidney Day, that it has found drug “recipes” to prevent most kidney failure.

The method was published in a peer-reviewed medical journal in September 2002, but has received little publicity since.

GenoMed’s approach reversed early kidney failure in white, black, and Hispanic patients with diabetes and high blood pressure. Diabetes and high blood pressure cause 90% of kidney failure in the US. Kidney failure affects people of color disproportionately more than whites.

The Centers for Medicaid and Medicare (CMS) currently pay $25 billion annually for kidney dialysis and transplantation. A typical dialysis patient costs $100,000 a year, and lives for less than 3 years on dialysis. When GenoMed’s CEO, Dr. David Moskowitz, briefed CMS about his paper in 2004, the Medical Director and his staff at CMS had no interest. Neither did the National Institutes of Health, nor any non-profit kidney association.

Said Dr. Moskowitz, "In medical school, we were exhorted to find cures. I wouldn't have believed it then if somebody had told me there was no point in finding a cure because news of the cure would be suppressed. Yet that's exactly what's happened for the past four and a half years."

Dr. Moskowitz continued, "Medicine, like any business, thrives on the status quo. Financially small disruptions can be tolerated, like finding cures for polio and TB in the 1950s. Other than the staff of the polio wards and the TB sanitaria, nobody in medicine was hurt financially. But eliminating 90% of a $25 billion a year industry is another thing altogether. Nobody in healthcare wants their budget or their revenues cut."

Added Dr. Moskowitz, “This is the real reason why healthcare costs keep rising. Medicine is fundamentally anti-innovative.”

March 8, 2007 - 9:31 AM EST

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From: Tadsamillionaire5/10/2007 1:18:48 AM
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West Nile Virus Victim Urges Awareness of GenoMed's Trial
GenoMed (PINKSHEETS: GMED), a Next-Generation Disease Management company whose business is public health(TM), today joined Sgt. Donnie Manry, a Bryan, Texas policeman recovering from paralysis due to West Nile virus, in urging greater public awareness of GenoMed's clinical trial for West Nile virus encephalitis.

Sgt. Manry contracted West Nile virus encephalitis in July 2006, becoming paralyzed from the waist down. Three weeks after his first symptoms, Sgt. Manry and his physician began GenoMed's treatment protocol, which they credit with speeding his recovery. But despite heroic effort, Sgt. Manry still cannot walk without assistance nearly a year later.

Sgt. Manry, who is scheduled to lose his police job in two months because of his continued paralysis, said, "I don't want anybody to have to go through what I did. I just wish I'd known about GenoMed's protocol sooner."

Added Sgt. Manry, "In my case it took over a week before West Nile virus was even confirmed. GenoMed's treatment should be started as a precautionary measure even before confirmation by the CDC lab."

Said GenoMed's CEO and Chief Medical Officer, David Moskowitz MD, "Mr. Manry has put in a superhuman effort to recover from this devastating disease, which has been well documented (http://www.topix.net/search/article?q=%22Donnie+Manry%22, and donniemanry.info). Our experience with other patients suggests that he would have gotten a lot better a lot faster if he'd begun our treatment right away, within the first two days rather than three weeks later."

Added Dr. Moskowitz, "The sooner brain inflammation is turned off, the lower the risk of paralysis. Knowing about our treatment ahead of time could make the difference between a quick recovery instead of prolonged paralysis."

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From: Tadsamillionaire7/5/2007 8:02:29 PM
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West Nile Identified in Connecticut Mosquitoes

State health officials reported Thursday that mosquitoes infected with the West Nile virus have been found in Manchester.

The mosquitoes trapped June 27 are the first West Nile-positive mosquitoes identified in the state this year, the Department of Public Health said.

This is the ninth year the West Nile virus has been found in Connecticut. Last year, the virus in mosquitoes or humans turned up in 25 towns.

Health officials are urging residents -- especially the elderly -- to take precautions to avoid mosquito bites. Symptoms in people include fever, headache, body aches, nausea or a rash
foxnews.com

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From: Tadsamillionaire7/14/2007 12:40:24 PM
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US: West Nile has infected 47 and killed three by July 13
By Ben Wasserman
Jul 14, 2007 - 7:40:42 AM
deaths from mosquito borne West Nile virus so far this year. The unlisted states did not report any human case. Some states did not update as quickly as others. Also the local health departments often do not report cases promptly. Therefore, the real numbers of human WNV are likely much higher.



We reviewed the reports published on individual states’ web sites on Friday July 13. Those who are concerned about the mosquito-borne disease need to pay attention to how to prevent mosquito bites. We cited an article from the CDC for readers’ reference.



Idaho (2/0): The state Department of Health and Welfare updated the West Nile virus activity on July 13 indicating that two persons were infected with the virus in the state, one from Ada County and the other from Payette County.



Nevada (1/0): Nevada State Health Division reported that so far, one person in Clark County was infected with West Nile virus. Last year, eight people were infected in the month of July during which none was found in Clark County.



California (9/1): Nine people were reportedly infected with West Nile Virus with eight in Kern County and one in Joanquin County. There was a death from the West Nile virus in Kern County. The virus seems to be more active this year than last year. In 2006, only one person was infected.



Wyoming (1/0): Wyoming Department of Health reported on July 3 its first human West Nile virus case in an adult male in Fremont County. Last year, the state had sixty five people infected with West Nile virus and two deaths from the infection.



North Dakota (9/0): North Dakota has reported nine cases of West Nile virus with four females and five males from five counties. Four people were hospitalized.



Minnesota (1/0): As of July 13, one person in Polk County of the state has been reportedly infected with West Nile virus.



Nebraska (8/0): Eight people from six counties including Boone (1), Platte (1), Lincoln (1), Hall (3), Adam (1), and Thayer (1) have been found positive for West Nile virus as far this year.



Colorado (3/0): Three people have tested positive for West Nile virus so far this year. One person was found in Boulder County, one from Cheyenne County and the third one from Logan County.



Texas (1/0): One person in Texas has been infected with West Nile virus so far this year. Last year, the virus caused 33 human deaths.



Iowa (2/0): As of July 13, two persons have been infected with West Nile virus.



Illinois (2/0): Two persons, one from Cook and the other from DuPage County have been infected with West Nile virus so far this year.



Mississippi (8/2): Eight people were reported to suffer from West Nile virus and two died from the disease this year in the state. One case was reported in Lawrence County, one in Madison, three in Rankin, one in Scott and one in Walthall.


foodconsumer.org

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From: Tadsamillionaire7/22/2007 7:14:29 PM
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Cuba establishes real-time bird flu detection system.

Cuba has established a monitoring system to detect bird flu, the country's public health ministry announced Friday.

The ministry's vice minister Gonzalo Estevez told a news conference in Havana that Cuba has trained personnel to face an avian flu epidemic such as the one affecting many countries in southeast Asia.

Estevez said Cuba has invested millions of dollars in the avian flu detection and control program and it is following the worldwide evolution of the epidemic.

"The threat of a possible worldwide avian-flu epidemic as well as its social and economic impact urged all the countries to be on the alert and to draw out contingency plans to deal with an emergency situation," Estevez said.

Bird flu is strong enough to infect different mammals, including humans, and has infected 306 people around the world since 2003, killing 185 of them.

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