| From: tnsaf | 1/30/2017 6:31:50 PM | | | | | | "The nervous and immune systems communicate and reciprocally influence their functional responses. Nature Immunology and Nature Neuroscience team up to present a joint focus issue comprising of specially commissioned review articles that examine how the nervous system and immune cells interact during development, during homeostasis and in pathogenic disease states."
nature.com |
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| From: nigel bates | 5/6/2017 8:30:38 AM | | | | | | Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism
pnas.org
Abstract
Effective control of endotoxins and bacteria is crucial for normal wound healing. During injury, the key enzyme thrombin is formed, leading to generation of fibrin. Here, we show that human neutrophil elastase cleaves thrombin, generating 11-kDa thrombin-derived C-terminal peptides (TCPs), which bind to and form amorphous amyloid-like aggregates with both bacterial lipopolysaccharide (LPS) and gram-negative bacteria. In silico molecular modeling using atomic resolution and coarse-grained simulations corroborates our experimental observations, altogether indicating increased aggregation through LPS-mediated intermolecular contacts between clusters of TCP molecules. Upon bacterial aggregation, recombinantly produced TCPs induce permeabilization of Escherichia coli and phagocytic uptake. TCPs of about 11 kDa are present in acute wound fluids as well as in fibrin sloughs from patients with infected wounds. We noted aggregation and colocalization of LPS with TCPs in such fibrin material, which indicates the presence of TCP-LPS aggregates under physiological conditions. Apart from identifying a function of proteolyzed thrombin and its fragments, our findings provide an interesting link between the coagulation system, innate immunity, LPS scavenging, and protein aggregation/amyloid formation. |
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| From: tnsaf | 9/24/2017 6:06:30 PM | | | | | | | The garbage masquerading as information on websites can be quite humorous. For example, this one appears to combines a template with a database that fills in blanks, but some of the fields in the database are empty: economicsandmoney.com. |
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| From: tnsaf | 5/23/2018 4:46:26 PM | | | | | | Diabetes Researchers Find Switch for Fatty Liver Disease
Interesting article in DDD Magazine on this topic
Duke researchers have identified a key fork in the road for the way the liver deals with carbohydrates, fats and protein. They say it could be a promising new target for combating the pandemics of fatty liver disease and prediabetes.
dddmag.com |
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