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Biotech / Medical : Smithkline Beecham (SBH)

SBH 10.05

-2.1%

1:00 PM EDT

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To: Mike Battin who wrote (34)	6/5/1998 9:57:00 AM
From: Henry Niman	of 61

Did anyone here see Ligand's presentations a few months ago about a small molecule mimic of G-CSF (Neupogen)? The results were quite unexpected (a small molecule could bind to the G-CSF receptor and mimic its effect). Rumor has it that the data will be published in a week or two in Science and it will be a major event. When I heard about the data in February, I added a web page on it (at home.att.net ). The presented data was on a molecule that was mouse specific (recognized the mouse receptor but not the human one), but I suspect that LGND has a human version now (their pipeline time table at home.att.net indicates that a human version has been selected (under their hematopoietic growth factor alliance with SBH). Anyone have any more details?

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