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To: scaram(o)uche who wrote (115)12/6/2002 12:11:13 PM
From: scaram(o)uche  Read Replies (1) of 146
Dr. William Claypool, 51................................................................ 2002 2005
Dr. William Claypool joined us as a director in January 2002. Dr. Claypool has
served as the CEO of Phoenix Data Systems, Inc. since June 2001. Dr. Claypool also
served as CEO of the GI Company from January 2001 to June 2001. From 1991 to
December 2000, Dr. Claypool held a number of key management positions of
increasing responsibility with SmithKline Beecham Pharmaceuticals. Most notably,
he was Senior Vice President and Worldwide Medical Director, Clinical Research
and Development from November 1998 to December 2000. Prior to his tenure with
SmithKline Beecham, Dr. Claypool was employed with G.D. Searle & Co. in
Clinical Research. Prior to beginning his career in industry, Dr. Claypool held
academic positions at the University of Pennsylvania School of Medicine, the
University of Pittsburgh School of Medicine, and the University of Illinois at
Chicago College of Medicine. He has been an active member of many organizations
including the American Thoracic Society, the American College of Chest
Physicians, the American Federation for Clinical Research, the Chicago Thoracic
Society, and the American Physiology Society. He has been published in many
highly regarded pharmaceutical publications as well. Dr. Claypool earned a B.S.
from the University of Notre Dame and an M.D. from the University of Connecticut
School of Medicine. He did his residency and fellowship at the Hospital of the
University of Pennsylvania.

Mr. Joshua Ruch, 52..................................................................... 1997 2005
Mr. Joshua Ruch has been a director with us since March 1997. Mr. Ruch is the
Chairman and Chief Executive Officer of Rho Capital Partners, Inc., an international
investment management firm which he co-founded in 1981. Prior to founding Rho
Capital Partners, Inc., Mr. Ruch was employed in investment banking at Salomon
Brothers and Bache Halsey Stuart, Inc. Mr. Ruch received a B.S. degree in electrical
engineering from the Israel Institute of Technology (Technion) and an MBA from
the Harvard Business School. Mr. Ruch also serves on the Board of Directors of
Diacrin, Inc., a public company, as well as several private companies in the
technology sector.

Dr. F. Raymond Salemme, 57.............................................................. 1993 2005
Dr. F. Raymond Salemme founded the Company in 1993, and has served as a
director since February 1993. Dr. Salemme currently serves as President and Chief
Scientific Officer, positions he has held since June 1998 and June 1996,
respectively. Dr. Salemme was Chairman of the Company from June 1996 to June
1998, and served as President and Chief Executive Officer from February 1993 to
June 1996. Dr. Salemme is co-inventor on 14 US patents covering our
DirectedDiversity(R) chemi-informatics process control technology and our
ThermoFluor assay technology. Prior to founding our company, Dr. Salemme
established drug discovery groups specializing in structure-based drug design,
biophysics, and computational chemistry at Sterling Winthrop Pharmaceuticals and
DuPont Merck Pharmaceuticals, Inc. Dr. Salemme also worked in Central Research
and Development at DuPont, where he led research in protein X-ray crystallography
and engineering, developed computational methods for crystallography and drug
design, and conducted large-scale computational simulations of proteins and
polymer systems. In 1983, Dr. Salemme founded the Protein Engineering Division
of Genex Corporation, among the first companies to use X-ray crystallography and
molecular modeling for genetically engineering proteins. From 1973 to 1983, Dr.
Salemme was Professor of Biochemistry at the University of Arizona and published
extensively in the areas of molecular structures of redox proteins, the theory of
biological electron transfer and protein architecture. Dr. Salemme received a B.A. in
Molecular Biophysics from Yale University (with exceptional distinction) and a
Ph.D. in Chemistry from the University of California, San Diego, where his Ph.D.
thesis solved one of the first high-resolution 3-D protein structures by X-ray
crystallography. In addition to duties at 3DP, Dr. Salemme serves on several
corporate scientific and academic advisory boards, as well as federal advisory
committees on advanced technology and biotechnology, including the National
Institute of Science and Technology (NIST) Visiting Committee on Advanced
Technology and advisory committees for the National Institutes of Health.
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