Biotech / Medical: Indications -- obesity/erectile dysfunction  
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Share This Board Moderated By: scaram(o)uche -- (Moderated) -- Started: 2/5/2001 11:56:05 PM  Revision History

indication-specific file folder for obesity and/or erectile dysfunction

first file entry........

Message 15303351

I figured my BMI is 30 now, not to happy about that.
I'll nibble for now, maybe try to flesh out this post
later, it is certainly a huge problem. (Heh)

Anyway, I'm sure we have all seen the nice summary--
Biotech weighs up the options in obesity
Alan Dove
Nature Biotechnology Volume 19 Number 1 Page 25 - 28 (2001)

Genset did not make the cut this time but I
am encouraged to think that the perceived value of
their secreted protein library will be going up these
next few years. GENXY is my third largest holding, and
I've promised the wife that I will take her to Paris in
a couple of years--of course, it will be at the time of
the annual meeting. 
I snagged this list off that site:
Leptin, Orlistat and sibutramine,

ß3 adrenergic (you know my puffer isn't keeping
me thin, must be the wrong receptor eh?)
-I found that Merck has found some potential
drugs here, experiments on dogs--See Pubmed
(The NatBio paper specifically mentioned Sanofi-
Synthelabo here)

Agouti related protein,
Corticotropin releasing hormone,
Histamine 3 receptor,
Melanin concentrating hormone,

Neuropeptide y --I have not seen anything new from
Synaptic recently, but here are a few hits off the net: 

...and Serotonin.

Maybe this is an interesting area?

I realize that folks can do their own googling around,
but there might be something here to help start off any newbies.
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350Proc Natl Acad Sci U S A. 2014 Jun 3. pii: 201406728. [Epub ahead of print] Thescaram(o)uche-06/14/2014 02:28 PM
349>> Efficacy is not an issue. In phase III testing, toxicity will be a big scaram(o)uche-04/22/2014 03:40 PM
348More Evidence Supports Obesity Drug Entering Clinical Trials Fri, 12/20/2013 - 1tnsaf-01/02/2014 01:02 AM
347Thanks! Efficacy is not an issue. In phase III testing, toxicity will be a bigscaram(o)uche-11/15/2013 10:19 AM
346Zafgen's P2 for it's MetAP2 inhibitor beloranib seems to have gone quitetuck-11/15/2013 10:14 AM
345Fighting Obesity With Gut Bacteria Sep 11, 2013NEW YORK (Reuters Health) Sep 11russet-09/17/2013 04:15 PM
344Brain Res. 2013 Sep 7. pii: S0006-8993(13)01169-4. doi: 10.1016/j.brainres.2013.scaram(o)uche-09/17/2013 12:28 PM
343Br J Pharmacol. 2013 Aug 28. doi: 10.1111/bph.12360. [Epub ahead of print] Ananscaram(o)uche-09/04/2013 01:57 PM
342FASEB J. 2013 Aug 27. [Epub ahead of print] The CB1 receptor mediates the peripscaram(o)uche-08/29/2013 07:03 PM
341So, let's see.... aspirin, ibuprofen, etc. And through a different routescaram(o)uche-08/28/2013 12:45 PM  Nature Neuroscience 16, 1291–1298 (2013) doi:10.1038/nn.3480 scaram(o)uche-08/28/2013 12:34 PM
339>> even includes at least one CB1R antagonist << er......... wellscaram(o)uche-08/03/2013 12:50 PM
338Between the lines, these investigators are saying that mixtures of phytocannabinscaram(o)uche-07/30/2013 02:37 PM
337Neuropsychopharmacology. 2013 Jun 24. doi: 10.1038/npp.2013.153. [Epub ahead of scaram(o)uche-06/27/2013 02:53 PM
336(emphasis mine, and it never did make sense that curcumin would both exhibit antscaram(o)uche-04/13/2013 02:17 PM
335Psychopharmacology (Berl). 2013 Mar 13. [Epub ahead of print] Dissociable effescaram(o)uche-03/15/2013 02:29 PM  (full text) (great read, from the six of one, hascaram(o)uche-03/07/2013 08:11 PM
333Neuropsychopharmacology. 2013 Feb 20. doi: 10.1038/npp.2013.51. [Epub ahead of pscaram(o)uche-03/05/2013 10:07 PM
332International Journal of Obesity Supplements (2012) 2, S7–S13; doi:10.1038/ijosuscaram(o)uche-12/14/2012 04:50 PM
331J Pharmacol Exp Ther. 2012 Nov 29. [Epub ahead of print] ANALYSIS OF TOLERANCEscaram(o)uche-12/02/2012 06:12 PM
330Protein Sci. 2012 Nov 26. doi: 10.1002/pro.2192. [Epub ahead of print] Moleculscaram(o)uche-11/28/2012 03:55 PM
329J Neurosci. 2012 Nov 21;32(47):16651-16665. The CB1 Cannabinoid Receptor Drivescaram(o)uche-11/25/2012 01:00 PM
328J Biol Chem. 2012 Nov 16. [Epub ahead of print] The cannabinoid receptor CB1 mscaram(o)uche-11/21/2012 12:08 PM
327>> You s'pose that issue is what torpedoed the GPR119 program at Arenascaram(o)uche-11/19/2012 01:41 PM
326Proc Natl Acad Sci U S A. 2012 Nov 12. [Epub ahead of print] Anti-inflammatoryscaram(o)uche-11/15/2012 10:41 AM
325I'm pretty certain that Dr. Yang should be turned loose on global warming, Iscaram(o)uche-11/14/2012 04:28 PM
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