Biotech / Medical
Indications -- obesity/erectile dysfunction
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Emcee:  scaram(o)uche Type:  Moderated
indication-specific file folder for obesity and/or erectile dysfunction

first file entry........

Message 15303351

I figured my BMI is 30 now, not to happy about that.
I'll nibble for now, maybe try to flesh out this post
later, it is certainly a huge problem. (Heh)

Anyway, I'm sure we have all seen the nice summary--
Biotech weighs up the options in obesity
Alan Dove
Nature Biotechnology Volume 19 Number 1 Page 25 - 28 (2001)

Genset did not make the cut this time but I
am encouraged to think that the perceived value of
their secreted protein library will be going up these
next few years. GENXY is my third largest holding, and
I've promised the wife that I will take her to Paris in
a couple of years--of course, it will be at the time of
the annual meeting.
I snagged this list off that site:
Leptin, Orlistat and sibutramine,

ß3 adrenergic (you know my puffer isn't keeping
me thin, must be the wrong receptor eh?)
-I found that Merck has found some potential
drugs here, experiments on dogs--See Pubmed
(The NatBio paper specifically mentioned Sanofi-
Synthelabo here)

Agouti related protein,
Corticotropin releasing hormone,
Histamine 3 receptor,
Melanin concentrating hormone,

Neuropeptide y --I have not seen anything new from
Synaptic recently, but here are a few hits off the net:

...and Serotonin.

Maybe this is an interesting area?

I realize that folks can do their own googling around,
but there might be something here to help start off any newbies.
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357Neurosci Lett. 2015 Apr 14. pii: S0304-3940(15)00297-9. doi: 10.1016/j.neulet.20scaram(o)uche-April 20
356 If you want the benefits of medical marijuana without the "unwanted side eDoc Bones-April 11
355Neurosci Lett. 2015 Apr 3. pii: S0304-3940(15)00273-6. doi: 10.1016/j.neulet.201scaram(o)uche-April 9
354J Neurosci. 2015 Mar 4;35(9):3879-3892. Corticotropin-Releasing Hormone Drives scaram(o)uche-March 6
353Proc Natl Acad Sci U S A. 2014 Dec 22. pii: 201421420. [Epub ahead of print] A scaram(o)uche-12/28/2014
352Arthritis Res Ther. 2014 Sep 27;16(5):437. [Epub ahead of print] Tapping into tscaram(o)uche-9/30/2014
351Front Neurol. 2014 Aug 28;5:161. doi: 10.3389/fneur.2014.00161. eCollection 2014scaram(o)uche-9/17/2014
350Proc Natl Acad Sci U S A. 2014 Jun 3. pii: 201406728. [Epub ahead of print] Thescaram(o)uche-6/14/2014
349>> Efficacy is not an issue. In phase III testing, toxicity will be a big scaram(o)uche-4/22/2014
348More Evidence Supports Obesity Drug Entering Clinical Trials Fri, 12/20/2013 - 1tnsaf-1/2/2014
347Thanks! Efficacy is not an issue. In phase III testing, toxicity will be a bigscaram(o)uche-11/15/2013
346Zafgen's P2 for it's MetAP2 inhibitor beloranib seems to have gone quitetuck-11/15/2013
345Fighting Obesity With Gut Bacteria Sep 11, 2013NEW YORK (Reuters Health) Sep 11russet-9/17/2013
344Brain Res. 2013 Sep 7. pii: S0006-8993(13)01169-4. doi: 10.1016/j.brainres.2013.scaram(o)uche-9/17/2013
343Br J Pharmacol. 2013 Aug 28. doi: 10.1111/bph.12360. [Epub ahead of print] Ananscaram(o)uche-9/4/2013
342FASEB J. 2013 Aug 27. [Epub ahead of print] The CB1 receptor mediates the peripscaram(o)uche-8/29/2013
341So, let's see.... aspirin, ibuprofen, etc. And through a different routescaram(o)uche-8/28/2013 Nature Neuroscience 16, 1291–1298 (2013) doi:10.1038/nn.3480 Receivscaram(o)uche-8/28/2013
339>> even includes at least one CB1R antagonist << er......... wellscaram(o)uche-8/3/2013
338Between the lines, these investigators are saying that mixtures of phytocannabinscaram(o)uche-7/30/2013
337Neuropsychopharmacology. 2013 Jun 24. doi: 10.1038/npp.2013.153. [Epub ahead of scaram(o)uche-6/27/2013
336(emphasis mine, and it never did make sense that curcumin would both exhibit antscaram(o)uche-4/13/2013
335Psychopharmacology (Berl). 2013 Mar 13. [Epub ahead of print] Dissociable effescaram(o)uche-3/15/2013 (full text) (great read, from the six of one, half dozscaram(o)uche-3/7/2013
333Neuropsychopharmacology. 2013 Feb 20. doi: 10.1038/npp.2013.51. [Epub ahead of pscaram(o)uche-3/5/2013
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