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Indications -- obesity/erectile dysfunction
An SI Board Since February 2001
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Emcee:  scaram(o)uche Type:  Moderated
indication-specific file folder for obesity and/or erectile dysfunction

first file entry........

Message 15303351

>>Obesity<<
I figured my BMI is 30 now, not to happy about that.
I'll nibble for now, maybe try to flesh out this post
later, it is certainly a huge problem. (Heh)

Anyway, I'm sure we have all seen the nice summary--
Biotech weighs up the options in obesity
Alan Dove
Nature Biotechnology Volume 19 Number 1 Page 25 - 28 (2001)

Genset did not make the cut this time but I
am encouraged to think that the perceived value of
their secreted protein library will be going up these
next few years. GENXY is my third largest holding, and
I've promised the wife that I will take her to Paris in
a couple of years--of course, it will be at the time of
the annual meeting.

obesity-news.com
I snagged this list off that site:
Leptin, Orlistat and sibutramine,
Axokine,

ß3 adrenergic (you know my puffer isn't keeping
me thin, must be the wrong receptor eh?)
-I found that Merck has found some potential
drugs here, experiments on dogs--See Pubmed
(The NatBio paper specifically mentioned Sanofi-
Synthelabo here)

Agouti related protein,
Corticotropin releasing hormone,
Dopamine,
Histamine 3 receptor,
Melanin concentrating hormone,
Melanocortin,

Neuropeptide y --I have not seen anything new from
Synaptic recently, but here are a few hits off the net:
arbl.cvmbs.colostate.edu
acnp.org
acnp.org
phoenixpeptide.com
medfarm.neuro.uu.se
clos.net

...and Serotonin.

Maybe this is an interesting area?
Orexins
endocrinology.org
siliconinvestor.com
the-scientist.com

I realize that folks can do their own googling around,
but there might be something here to help start off any newbies.
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ReplyMessage PreviewFromRecsPosted
350Proc Natl Acad Sci U S A. 2014 Jun 3. pii: 201406728. [Epub ahead of print] Thescaram(o)uche-June 14
349>> Efficacy is not an issue. In phase III testing, toxicity will be a big scaram(o)uche-April 22
348More Evidence Supports Obesity Drug Entering Clinical Trials Fri, 12/20/2013 - 1tnsaf-January 2
347Thanks! Efficacy is not an issue. In phase III testing, toxicity will be a bigscaram(o)uche-11/15/2013
346Zafgen's P2 for it's MetAP2 inhibitor beloranib seems to have gone quitetuck-11/15/2013
345Fighting Obesity With Gut Bacteria Sep 11, 2013NEW YORK (Reuters Health) Sep 11russet-9/17/2013
344Brain Res. 2013 Sep 7. pii: S0006-8993(13)01169-4. doi: 10.1016/j.brainres.2013.scaram(o)uche-9/17/2013
343Br J Pharmacol. 2013 Aug 28. doi: 10.1111/bph.12360. [Epub ahead of print] Ananscaram(o)uche-9/4/2013
342FASEB J. 2013 Aug 27. [Epub ahead of print] The CB1 receptor mediates the peripscaram(o)uche-8/29/2013
341So, let's see.... aspirin, ibuprofen, etc. And through a different routescaram(o)uche-8/28/2013
340nature.com Nature Neuroscience 16, 1291–1298 (2013) doi:10.1038/nn.3480 Receivscaram(o)uche-8/28/2013
339>> even includes at least one CB1R antagonist << er......... wellscaram(o)uche-8/3/2013
338Between the lines, these investigators are saying that mixtures of phytocannabinscaram(o)uche-7/30/2013
337Neuropsychopharmacology. 2013 Jun 24. doi: 10.1038/npp.2013.153. [Epub ahead of scaram(o)uche-6/27/2013
336(emphasis mine, and it never did make sense that curcumin would both exhibit antscaram(o)uche-4/13/2013
335Psychopharmacology (Berl). 2013 Mar 13. [Epub ahead of print] Dissociable effescaram(o)uche-3/15/2013
334jpet.aspetjournals.org (full text) (great read, from the six of one, half dozscaram(o)uche-3/7/2013
333Neuropsychopharmacology. 2013 Feb 20. doi: 10.1038/npp.2013.51. [Epub ahead of pscaram(o)uche-3/5/2013
332International Journal of Obesity Supplements (2012) 2, S7–S13; doi:10.1038/ijosuscaram(o)uche-12/14/2012
331J Pharmacol Exp Ther. 2012 Nov 29. [Epub ahead of print] ANALYSIS OF TOLERANCEscaram(o)uche-12/2/2012
330Protein Sci. 2012 Nov 26. doi: 10.1002/pro.2192. [Epub ahead of print] Moleculscaram(o)uche-11/28/2012
329J Neurosci. 2012 Nov 21;32(47):16651-16665. The CB1 Cannabinoid Receptor Drivescaram(o)uche-11/25/2012
328J Biol Chem. 2012 Nov 16. [Epub ahead of print] The cannabinoid receptor CB1 mscaram(o)uche-11/21/2012
327>> You s'pose that issue is what torpedoed the GPR119 program at Arenascaram(o)uche-11/19/2012
326Proc Natl Acad Sci U S A. 2012 Nov 12. [Epub ahead of print] Anti-inflammatoryscaram(o)uche-11/15/2012
325<i>I'm pretty certain that Dr. Yang should be turned loose on global wscaram(o)uche-11/14/2012
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