Copyright © 2013 Knight Sac Media. All rights reserved.http://www.siliconinvestor.com/subject.aspx?subjectid=52733Forum for indication specific information.http://www.siliconinvestor.com/images/Logo380x132.pnghttp://www.siliconinvestor.com/subject.aspx?subjectid=5273338013210scaram(o)uchehttp://www.siliconinvestor.com/readmsg.aspx?msgid=289544996/16/2013 11:12:38 AMnigel batesPreventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment pnas.org  Gwenaëlle Douauda,b,1, Helga Refsumb,c,d, Celeste A. de Jagerc, Robin Jacobye, Thomas E. Nicholsa,f,g,Stephen M. Smitha, and A. David Smithb,c Edited by Marcus E. Raichle, Washington University in St. Louis, St. Louis, MO, a...http://www.siliconinvestor.com/readmsg.aspx?msgid=289543416/16/2013 3:52:07 AMscaram(o)ucheCell Death Dis. 2013 Apr 4;4:e580. doi: 10.1038/cddis.2013.111. Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death. Brennan-Minnella AM, Shen Y, Swanson RA. Department of Neurology, San Francisco Veterans Affairs Medical Center, University of California, San Franc...http://www.siliconinvestor.com/readmsg.aspx?msgid=288219544/8/2013 10:40:08 AMscaram(o)ucheExp Gerontol. 2013 Mar 4. pii: S0531-5565(13)00065-X. doi: 10.1016/j.exger.2013.02.025. [Epub ahead of print] PI3-kinase/Akt/mTOR signalling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease. Neill CO. Department of Biochemistry, BioSciences Institute, University College Cork, Ireland....http://www.siliconinvestor.com/readmsg.aspx?msgid=287934653/22/2013 11:34:38 AMnigel batesDoubt cast on the efficacy of targeting alpha-synuclein to treat Parkinson's: bloomberg.com  "...The experimental technique involves reducing levels of alpha-synuclein, a protein found in clumps in the brains of people with Parkinson’s that increases the risk of the disease. Research presented at the American Academ...http://www.siliconinvestor.com/readmsg.aspx?msgid=287906423/21/2013 9:40:53 AMmopgcwResearch Offers New Hope for Multiple Sclerosis Scientists have converted human skin cells into brain cells and used them to treat mice with myelin disorders, a family of diseases that includes multiple sclerosis. The research, reported Thursday, marks another promising advance for a technique known as cell reprogr...http://www.siliconinvestor.com/readmsg.aspx?msgid=287142722/8/2013 1:38:10 PMtnsaf Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis Nature Biotechnology (2012) doi:10.1038/nbt.2434 nature.com  Received 29 May 2012 Accepted 30 October 2012 Published online 18 November 2012 Abstract Aberrant T-cell activation underlies...http://www.siliconinvestor.com/readmsg.aspx?msgid=2856762711/25/2012 11:25:32 PMrussetNew Risk Variant for Alzheimer's Disease Discovered Megan Brooks Nov 14, 2012 A new study strongly implicates a variant in the gene encoding the triggering receptor expressed on myeloid cells 2 ( TREM2) in the pathogenesis of Alzheimer's disease (AD). TREM2 has an antiinflammatory role in the brain. "Reduced TRE...http://www.siliconinvestor.com/readmsg.aspx?msgid=2855124111/15/2012 6:30:24 PMscaram(o)ucheJ Biol Chem. 2012 Nov 5. [Epub ahead of print] Identification of Three Residues Essential for 5-HT2A-mGlu2 Receptor Heteromerization and its Psychoactive Behavioral Function. Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuellar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, Lopez-...http://www.siliconinvestor.com/readmsg.aspx?msgid=2852927211/7/2012 10:04:53 AMJohn McCarthyThis is off topic but maybe interesting to some ..... Denisova at high coverage Thu, 2012-08-30 15:25 -- John Hawks http://johnhawks.net/weblog/reviews/denisova/denisova-high-coverage-2012.html Science today has released the new paper on the Denisova high-coverage genome by Mattias Meyer and colleagues from Svante...http://www.siliconinvestor.com/readmsg.aspx?msgid=284176929/18/2012 7:44:14 PMmopgcwBiotechnology R. Mehrotra Multiple Sclerosis - Some thoughts on 3rd Laquinimod PIII, More of a FINALE than a CONCERTO Yesterday Teva and Active Biotech announced the initiation of a 3rd oral laquinimod PIII study under a SPA. The new disability focused trial is aptly named CONCERTO, following on from the completed ...http://www.siliconinvestor.com/readmsg.aspx?msgid=283246088/9/2012 2:20:59 PMJohn McCarthyChronic 'Butter Flavoring' Exposure Linked to Harmful Brain Process [graphic]HealthDay – 57 mins ago MONDAY, Aug. 6 (HealthDay News) -- Chronic exposure to an artificial butter flavoring ingredient, known as diacetyl, may worsen the harmful effects of a protein in the brain linked to Alzheimer's disease, according to ...http://www.siliconinvestor.com/readmsg.aspx?msgid=283179188/6/2012 3:13:42 PMDewDiligence_on_SIGammagard shows promising results in small phase-2 extension study: investorshub.advfn.com http://www.siliconinvestor.com/readmsg.aspx?msgid=282733647/17/2012 6:26:47 PMrussetScientists Identify Protein Required to Regrow Injured Nerves in Limbs siliconinvestor.com [graphic]enlarge [graphic] These are images of axon regeneration in mice two weeks after injury to the hind leg’s sciatic nerve. On the left, axons (green) of a normal mouse have regrown to their targets (red) in the muscle....http://www.siliconinvestor.com/readmsg.aspx?msgid=282211956/21/2012 10:14:16 PMDewDiligence_on_SII would suggest that you check out other resurfacing options; some of them may employ ceramic materials rather than all metal. There are several manufacturers of these kits; however, many orthopedic surgeons work with only one company so they may not be the best source of information about the choices available. As ...http://www.siliconinvestor.com/readmsg.aspx?msgid=281687785/25/2012 11:13:57 AMbmaz001Thanks, Dew. Unfortunately, the non metal-on-metal options (that I'm aware of) are in the 'total hip replacement' category. That approach involves lopping off a large section of the upper femur. Hip resurfacing is very different in that the 'ball' of the femur is slightly ground down and then 'capped'. The 'kit' th...http://www.siliconinvestor.com/readmsg.aspx?msgid=281686785/25/2012 10:27:14 AMDewDiligence_on_SIThere are product options for hips that do not involve metal-on-metal technology, so you should be able to avoid whatever incremental risk the stray metal ions might induce. Regards, Dewhttp://www.siliconinvestor.com/readmsg.aspx?msgid=281674365/24/2012 4:01:36 PMbmaz001Alzheimer's, metal ions and hip resurfacing- Alzheimer's has been in my mother's family for at least a few generations, so I'm assuming that I may be genetically predisposed to contracting this terrible disease someday. As I've aged, I've become more curious about AD and I've read that there may be an association betw...http://www.siliconinvestor.com/readmsg.aspx?msgid=281647505/23/2012 2:53:12 PMmopgcwcorrected link[url=http://the-scientist.com/2012/05/23/could-stem-cells-cure-ms/] the-scientist.com http://www.siliconinvestor.com/readmsg.aspx?msgid=281643435/23/2012 12:55:55 PMmopgcwhttp://www.siliconinvestor.com/readmsg.aspx?msgid=281641885/23/2012 12:03:48 PMtuckAn Alzheimer's prevention trial using Genentech's crenezumab, an antibody against amyloid, in Colombian patients with mutated amyloid pathways (the only sort of population on which such a trial could be ethically done): pipeline.corante.com  Cheers, Tuckhttp://www.siliconinvestor.com/readmsg.aspx?msgid=281512965/17/2012 10:47:11 AMtnsafAnother biomarker emerging for Alzheimer's links.mkt1985.com  The search for Alzheimer's disease biomarkers goes on, with a number of biomarkers beginning to emerge. The latest research focuses on biomarkers that signal damage to neurons, which might allow doctors to spot decline at an early stage. In the research pub...http://www.siliconinvestor.com/readmsg.aspx?msgid=279960143/7/2012 1:43:12 PMscaram(o)ucheEndocrinology. 2011 Nov 22. [Epub ahead of print] Topiramate Treatment Protects Blood-Brain Barrier Pericytes from Hyperglycemia-Induced Oxidative Damage in Diabetic Mice. Price TO, Eranki V, Banks WA, Ercal N, Shah GN. Division of Endocrinology (T.O.P., V.E., G.N.S.), Department of Internal Medicine, Saint Louis...http://www.siliconinvestor.com/readmsg.aspx?msgid=2779865912/1/2011 2:24:46 PMnigel bates [Alzheimer's as an infectious disease?] Well, it's already associated with HSV infection - (eg) plosone.org  - which is rather more easily transmissible than by direct injection to brain. Worth keeping an eye on, though.http://www.siliconinvestor.com/readmsg.aspx?msgid=2770614710/17/2011 8:11:29 AMtuck[Alzheimer's as an infectious disease?] >>Molecular Psychiatry , (4 October 2011) | doi:10.1038/mp.2011.120 De novo induction of amyloid-ß deposition in vivo R Morales, C Duran-Aniotz, J Castilla, L D Estrada and C Soto Abstract Alzheimer's disease (AD), the most common type of senile dementia, is associated to ...http://www.siliconinvestor.com/readmsg.aspx?msgid=2768497910/6/2011 1:29:52 PMscaram(o)ucheJ Neuroinflammation. 2011 Aug 18;8(1):102. [Epub ahead of print] Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors. Mestre L, Inigo PM, Mecha M, Correa FG, Hernangomez-Herrero M, Lori...http://www.siliconinvestor.com/readmsg.aspx?msgid=275854678/22/2011 9:59:01 AM