Copyright © 2013 Knight Sac Media. All rights reserved.http://www.siliconinvestor.com/subject.aspx?subjectid=31045This thread is a place for people to deposit news concerning biotechnology, biochemistry or biology that doesn't fit well into another thread. If you have a juicy bit of news and don't want to pollute an unrelated thread with it, dump it here. But please no toxic waste, bio-grade pollution only. ...http://www.siliconinvestor.com/images/Logo380x132.pnghttp://www.siliconinvestor.com/subject.aspx?subjectid=3104538013210scaram(o)uchenejm.org  With respect to clinical benefit, triple therapy, with sulfasalazine and hydroxychloroquine added to methotrexate, was noninferior to etanercept plus methotrexate in patients with rheumatoid arthritis who had active disease despite methotrexate therapy.http://www.siliconinvestor.com/readmsg.aspx?msgid=289473306/12/2013 10:02:05 AMIRWIN JAMES FRANKELCouple of interesting MS articles: sciencedaily.com  Enhanced White Blood Cells Heal Mice With MS-Like Disease June 1, 2013 — Genetically engineered immune cells seem to promote healing in mice infected with a neurological disease similar to multiple sclerosis (MS), cleaning up lesions and allowing the mice to regain...http://www.siliconinvestor.com/readmsg.aspx?msgid=289310866/3/2013 7:26:48 PMnigel batesWe all have around 200 different types of fungi colonising our feet... bbc.co.uk http://www.siliconinvestor.com/readmsg.aspx?msgid=289146885/24/2013 9:44:05 PMtom popeWhat blows my mind as a total layman (knowledge naive) is the way the scientists involved can burrow around the interior of a cell like they were driving down I-95.http://www.siliconinvestor.com/readmsg.aspx?msgid=288305914/12/2013 8:46:00 AMidosThe PCSK9 story Genetics: A gene of rare effect A mutation that gives people rock-bottom cholesterol levels has led geneticists to what could be the next blockbuster heart drug. By Stephen S. Hall 09 April 2013 nature.com http://www.siliconinvestor.com/readmsg.aspx?msgid=288305374/12/2013 8:25:43 AMGermanecki UPDATED: FDA proposes to dramatically lower the bar on Alzheimer's drugs March 14, 2013 | By John Carroll fiercebiotech.com http://www.siliconinvestor.com/readmsg.aspx?msgid=287780233/14/2013 12:44:25 PMBiotech JimI have read much of the Nature paper now and the problems in my view are the data underlying fig s4. That is, the proteins that interact with and thus are functionally associated with the specific HDACs and LDACs. Here is a quote from the paper 'that appears to stretch the truth.' "Page 2 of pdf: 878 genetic inte...http://www.siliconinvestor.com/readmsg.aspx?msgid=287750683/12/2013 5:30:26 PMtom popeHaving reread the article with your explanation in mind, I understand better now. Thanks.http://www.siliconinvestor.com/readmsg.aspx?msgid=287745773/12/2013 1:48:33 PMBiotech JimAs I read the news article, the issue seems to be with the threshold used to pick up the putative interactions, and thus would have no basis. The proteins are similar to HDACs, called LDACs and their functions are not well understood but these proteins were discovered via their modification of histones and chromatin ul...http://www.siliconinvestor.com/readmsg.aspx?msgid=287744173/12/2013 12:55:32 PMtom popeWashPost. Skullduggery at Johns Hopkins. It's not quite clear to me what were the precise grounds for Yuan's reservations, tho. washingtonpost.com http://www.siliconinvestor.com/readmsg.aspx?msgid=287742503/12/2013 11:50:08 AMDewDiligence_on_SITable of Major FoB Collaborations (updated with lots of new info): investorshub.advfn.com http://www.siliconinvestor.com/readmsg.aspx?msgid=287173332/10/2013 2:13:10 PMRon_The Operating Room of the Future - InSightec - Dr. Kobi Vortman Technion Alumnus youtube.com http://www.siliconinvestor.com/readmsg.aspx?msgid=287172152/10/2013 1:12:46 PMtnsafSynthetic human feces Researchers at the University of Guelph believe they’ve given doctors a new weapon in the fight against the pernicious stomach disease Clostridium difficile,which is a problem for patients in hospitals the world over. That weapon? Synthetic human feces. DubbedRePOOPulate by the researchers who cre...http://www.siliconinvestor.com/readmsg.aspx?msgid=286529871/9/2013 12:21:59 PMtom popeWSJ The Future of Medicine Is Now From cancer treatments to new devices to gene therapy, a look at six medical innovations that are poised to transform the way we fight disease [graphic] Reporter Ron Winslow talks to WSJ weekend Review editor Gary Rosen about astonishing medical advances t...http://www.siliconinvestor.com/readmsg.aspx?msgid=2863201612/29/2012 1:55:30 PMArthur Radleyhttp://www.siliconinvestor.com/readmsg.aspx?msgid=2862555212/25/2012 6:20:23 PMIRWIN JAMES FRANKELhttp://www.siliconinvestor.com/readmsg.aspx?msgid=2861059512/17/2012 4:28:42 PMtom popehttp://www.siliconinvestor.com/readmsg.aspx?msgid=2861056912/17/2012 4:21:46 PMIRWIN JAMES FRANKELhttp://www.siliconinvestor.com/readmsg.aspx?msgid=2860960612/17/2012 11:09:33 AMIRWIN JAMES FRANKELhttp://www.siliconinvestor.com/readmsg.aspx?msgid=2859451912/10/2012 7:09:34 AMtnsafNot biotech, but interesting tech: Next Generation: Ear-Powered Batteries Device:Researchers have for the first time harvested the energy of the inner ear to power a small sensing device. The electric potential of the cochlea operates like a biological battery and is critical for transforming sound pressure waves into...http://www.siliconinvestor.com/readmsg.aspx?msgid=2855557311/17/2012 9:47:54 PMtom popeNYT New Drugs for Lipids Set Off Race By ANDREW POLLACK LOS ANGELES — A new class of powerful cholesterol-reducing drugs is showing promising results, potentially offering a new option for people who do not respond to medication now on the market, according to studies presented at a conference of hea...http://www.siliconinvestor.com/readmsg.aspx?msgid=2852652911/6/2012 2:25:45 PMtom popeWSJ Gene-Therapy Approval Marks Major Milestone By JEANNE WHALEN The European Union has approved for sale the Western world's first gene-therapy drug, a type of medicine that introduces functioning genes to patients whose defective genes cause disease. The costly drug, which treats a rare metab...http://www.siliconinvestor.com/readmsg.aspx?msgid=2851835211/2/2012 7:37:04 PMpleonasticYet more major news for BSD Medical. Today's news is for another of their products, the BSD-2000. They have several products that are making news. For today's news see: http://investor.bsdmedical.com/press-release/clinical-trials-and-research/bsd-medical-reports-clinical-study-demonstrates-threefold or visit this ...http://www.siliconinvestor.com/readmsg.aspx?msgid=2849269510/23/2012 10:40:39 AMTonny JohnsonMetabolon vs. Stemina: Are Biomarker Patents can be Considered as “True Inventions”? This scientific blog critically analyzes the limitations and pitfalls in biomarker patent process. According to the argument made in this blog, most of the biomarkers patents may not have commercial prospective, though patents are i...http://www.siliconinvestor.com/readmsg.aspx?msgid=2847674210/16/2012 1:06:14 PMpleonasticThe following important news was reported on the BSD Medical SI board, but it has significance beyond the news release. The NR was about a single product (product line, actually), while it is just one successful application of an emerging therapy that rivals the mainline cancer therapies of surgery, radiotherapy, and ...http://www.siliconinvestor.com/readmsg.aspx?msgid=2847261710/14/2012 3:56:03 PMnigel bateshttp://www.siliconinvestor.com/readmsg.aspx?msgid=2846046810/8/2012 4:06:29 PMpleonasticAnyone interested in the “fourth pillar” for cancer treatment? Not just another drug or another method for delivering “hard” (ionizing) radiation to treat cancer. Instead, a new type of therapy -- proven safe and effective -- that works very well for ablating (destroying) tumors and also strongly augments (adjuvant u...http://www.siliconinvestor.com/readmsg.aspx?msgid=2845243410/4/2012 11:49:02 AMIan@SIReader response to yesterday's investigative reports including a couple more anecdotal side effect reports. thestar.com http://www.siliconinvestor.com/readmsg.aspx?msgid=284382549/27/2012 6:06:11 PMIan@SIYou may be interested in this investigation of ADHD drugs done by the Toronto Star... thestar.com  this was the Front Page story: thestar.com  Adverse Reaction Report No. 324764 Submitted by: Health Professional Date: 2009 Location: Canada Patient: Male Age: 15 years old Suspect Drug: Strattera Side Effect:...http://www.siliconinvestor.com/readmsg.aspx?msgid=284355269/26/2012 4:14:45 PMnigel batesInteresting new book out this week: guardian.co.uk  "....Because researchers are free to bury any result they please, patients are exposed to harm on a staggering scale throughout the whole of medicine. Doctors can have no idea about the true effects of the treatments they give. Does this drug really work best, or h...http://www.siliconinvestor.com/readmsg.aspx?msgid=284346799/26/2012 11:32:37 AMnigel bateshttp://www.siliconinvestor.com/readmsg.aspx?msgid=284307309/24/2012 4:31:43 PMtom pope09-23) 11:00 PDT SAN FRANCISCO -- In a move that could alter the way that breast cancers are treated, researchers have redefined the disease into four main classes and determined that one type of breast cancer has more in common with an aggressive form of ovarian cancer than other breast cancers.The finding that a ...http://www.siliconinvestor.com/readmsg.aspx?msgid=284288869/23/2012 6:42:12 PMidoshttp://www.siliconinvestor.com/readmsg.aspx?msgid=284083989/14/2012 10:55:59 AMtnsafFDA Reviews the Use of Progression-Free Survival in Cancer Trials medscape.com  Requires an account, which is free, to read the article. Jasonhttp://www.siliconinvestor.com/readmsg.aspx?msgid=283589428/24/2012 4:17:24 PMDewDiligence_on_SIhttp://www.siliconinvestor.com/readmsg.aspx?msgid=282634987/12/2012 10:15:29 PMnigel batesLondon, United Kingdom, 11 July 2012: Shionogi-ViiV Healthcare LLC today announced that initial results have been received from the Phase III SINGLE (ING114467) study of the investigational integrase inhibitor dolutegravir in treatment-naïve adults with HIV-1. The study demonstrated superiority of the dolutegravir-base...http://www.siliconinvestor.com/readmsg.aspx?msgid=282610687/12/2012 3:01:19 AMnigel batesFDA actions contribute to severe shortage of generic injectables: oversight.house.gov http://www.siliconinvestor.com/readmsg.aspx?msgid=282166996/20/2012 3:07:03 AMtnsafMarker Distinguishes More-Aggressive From Less-Aggressive Forms Of Chronic Leukemia fiercebiotech.com  •People newly diagnosed with chronic leukemia must often wait to learn if they have a faster- or slower-progressing form of the disease. •This study identified a molecular marker that quickly helps to distinguish w...http://www.siliconinvestor.com/readmsg.aspx?msgid=282057886/14/2012 12:31:39 AMDick MartinSirona Biochem Corp - a small biotech with interesting technology. sironabiochem.com http://www.siliconinvestor.com/readmsg.aspx?msgid=281945066/7/2012 8:02:34 PMRon_DNDN. Dendreon is positioning Provenge to become foundation of care. that would be HUGE. Provenge Has A Bigger Market Than You Think. seekingalpha.com http://www.siliconinvestor.com/readmsg.aspx?msgid=281930366/7/2012 9:49:27 AMtnsafWhen it comes to weight loss, watch the blood biomarkers and not the scale Read the story in FierceBiomarkershttp://www.siliconinvestor.com/readmsg.aspx?msgid=281925376/7/2012 12:04:54 AMtnsafI am wondering if anyone has done any work on diabetes stocks? Thank you. Check this board: Link: SI Subject 51391 Jasonhttp://www.siliconinvestor.com/readmsg.aspx?msgid=281925246/6/2012 11:53:20 PMJack O Bhttp://www.siliconinvestor.com/readmsg.aspx?msgid=281912026/6/2012 1:54:07 PMtnsafOpinion: Misleading Drug Trials Amgen’s incomplete report on an early major trial of epoetin misled the medical community about the anemia drug’s risks and benefits—and helped make Amgen rich. By Daniel W. Coyne | May 14, 2012 http://the-scientist.com/2012/05/14/opinion-misleading-drug-trials/ The Normal Hematocrit ...http://www.siliconinvestor.com/readmsg.aspx?msgid=281547105/18/2012 1:07:06 PMtnsafMismarketed Chemical Causes Concern An incorrect isomer of the kinase inhibitor bosutinib is circulating in the biomedical research community, potentially throwing doubt on study results. By Sabrina Richards | May 13, 2012 http://the-scientist.com/2012/05/13/mismarketed-chemical-causes-concern/ Some biochemical com...http://www.siliconinvestor.com/readmsg.aspx?msgid=281486115/16/2012 11:32:10 AMRon_4:23 PM The FDA votes 18-4-1 to recommend Arena Pharmaceutical's ( ARNA) weight loss drug, lorcaserin to the FDA regulators for approval or rejection. Shares currently halted.http://www.siliconinvestor.com/readmsg.aspx?msgid=281372405/10/2012 4:34:56 PMidosBasic research Scientists Uncover Exciting Lead Into Premature Ageing And Heart Diseasehttp://www.siliconinvestor.com/readmsg.aspx?msgid=281154574/30/2012 1:21:18 PMtom popeWSJ. Will paste full article if any interest. <> A growing number of patient-advocacy groups are playing matchmaker, linking patients to researchers who need them for clinical trials. The move comes as a persistent shortage of volunteers has slowed trials of new treatments for cancer and other diseases, which typ...http://www.siliconinvestor.com/readmsg.aspx?msgid=281009424/23/2012 8:21:10 PMrussetHow our brains are wired: Scanner reveals inner workings in stunning new detail By Ted Thornhill PUBLISHED: 10:04 GMT, 30 March 2012 | UPDATED: 15:31 GMT, 30 March 2012 dailymail.co.uk  For a long time it was thought that the brain was a mass of tangled wires, but researchers recently found that its fibe...http://www.siliconinvestor.com/readmsg.aspx?msgid=280780924/12/2012 3:07:28 PMBiotech JimLLY gets nod for Amyvid for AD from the FDA. This is a diagnostic for the detection of CNS b-amyloid. finance.yahoo.com http://www.siliconinvestor.com/readmsg.aspx?msgid=280690994/9/2012 7:33:42 AM