Silicon Investor (SI) -- The First Internet Community

To: Biomaven who wrote (491)

5/21/2012 1:12:16 PM

From: ghmm

I found the imbalance in acute exacerbation very interesting especially given no meaningful difference in FVC. I would suspect this led to the mortal imbalance as well (but I didn't see it mentioned in the paper). I wonder if azathioprine and/or prednisone triggered this in some patients. I've seen theories on these drugs being beneficial in some patients and yet harmful in others (if there are really different underlying diseases that would make a lot of sense).

The NAC arm is continuing and past studies with NAC have shown some promise. I'd still like to see ITMN do some combo trials perhaps a small investigator trial would be a cheap/low risk way to do this. I believe they mentioned in Germany some are already trying this.