Biotech / Medical | biotech fireworks


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To: sainte-beuve who wrote (5912)3/5/2012 7:07:20 PM
From: tom pope   of 6109
 
I first saw it in a post on the Biotech values board, but can't remember who brought it up. I certainly haven't seen anything that would justify such a parabolic move. There have been a few Seeking Alpha articles, but I'm sure you've seen those, and making it to Seeking Alpha is not necessarily a recommendation. If you find a good site hat seems well informed on IMUC, please share.

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To: sainte-beuve who wrote (5912)3/5/2012 9:55:44 PM
From: tom pope   of 6109
 
BTW, if you do get knowledgeable people to comment, you'll probably find that there are a lot of skeptics around cancer vaccines. DNDN burned a few people.
Maybe IMUC is different.

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To: tom pope who wrote (5914)3/6/2012 7:15:52 AM
From: sainte-beuve   of 6109
 
IMUC - I've had a position for a long time, ever since it was mentioned by Gary Grobbel on Microcap Kitchen thread over a year ago. Here is a copy of one of his posts from last year. Remember: this is an older post. I still can't explain recent activity.



older post...
IMUC...this guy is pretty well informed IMO over on SA-IMUC presents results at world cancer conf tomorrow stock up .25 to 2.28...

Already labeled as a stock to watch for its year-long price increase and powerful pipeline potential, shares of Immunocellular (IMUC.OB) broke through the two dollar mark again on Tuesday after announcing that the company had been granted a key patent to regarding its cancer-fighting technology.

The patent, numbered 7,939,090, was titled “System and method for the treatment of cancer, including cancers of the central nervous system,” according to a press release issued on Tuesday, and "covers the combination of a dendritic cell based vaccine combined either before or concurrently with chemotherapy at the recurrence of the disease."

This was a key patent award for Immuncellular Thereapeutics, as the company entrenches itself as a frontrunner to usher in the next generation of cancer immunotherapies.

As I've discussed in previous publishings, Immunocellular;s technology essentially picks up where the cancer vaccines of today have left off, and targets the stem cells that lead to cancer spreading and growth.

IMUC's lead candidate, ICT-107, is currently being tested with that technology in a Phase II trial for glioblastoma (GBM) that began earlier this year. Phase I results were highly encouraging and full enrollment for the current trial is expected to be achieved early in 2012, with results rolling out the following year.

As ICT-107 progresses through trials, it's worth highlighting the benefits of this product candidate, and the associated science behind IMUC's "next generation" product candidates.

A good starting point is noting that patients utilizing ICT-107 need only to have their dendritic cells 'harvested' once for the treatment to be processed and manufactured, while patients being treated with Dendreon's Provenge, for instance, need to go through the 'harvesting' procedure up to four times before it's all said and done.

The one-time harvesting process reduces the logistical and manufacturing costs for the company, which translates into better value on the market. It also potentially translates into lower costs for the patient and/or insurance company who picks up the tab, not mention the easing of inconveniences for the patient who will only endure the harvesting process once.


Tuesday's five percent price jump in the IMUC share price was a show of confidence for the technology behind the latest patent award, but with a market cap of under sixty million, this company may still be undervalued when taking into consideration the future market potential of its pipeline. As the Phase II trial progresses, it's likely that shares will continue to march upwards, and if results turn out as solid as earlier trials, then a move such as the one Keryx (KERX) enjoyed following positive Phase IIs could materialize.

In the meantime, cancer immunotherapies are a hot sector right now, as demonstrated by a very significant Oncothyreon (ONTY) run this year, and IMUC is primed to benefit from any positive developments in the sector.

Regarding Tuesday's patent announcement, which delivers additional credibility to this company as it began to get noticed on the 'buy' radars outside of just the speculative sector, ImmunoCellular CEO, Dr. Manish Singh said that, “This patent has applicability to multiple types of cancer, including our first clinical target, glioblastoma. ICT-107, the Company’s dendritic cell based vaccine candidate for the treatment of GBM, elicits a cytotoxic tumor reactive response that in combination with chemotherapy might fundamentally alter tumors by priming their death machinery.”

The Immunocellular path to the future is in place, the results - thus far - have been promising, what comes next is enough new investors taking notice and propelling the share price higher. This is something that might be helped out by a move to a larger exchange, something that the company has previously discussed, as there's a core of investors out there that won't touch OTCBB stocks.

The developments continue to come in positive for IMUC, keep it on the radar.

Disclosure: No position.

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From: fred hayes3/6/2012 9:45:35 AM
   of 6109
 
xoma up 22 percent to 1.77 while announcing offering, with warrants, at 1.32. Maybe someone can 'splain that one to me...(:>)!

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To: Jibacoa who wrote (5688)3/6/2012 11:11:39 AM
From: Jibacoa   of 6109
 
DUSA doing well in spite of the general market.<g>
The stock is up 21.50% on more than 4x its ADV, after reporting its 4thQ and full year results.
finance.yahoo.com 

The stock opened with an UG and it is still trading close to its intraday H. <g>
bigcharts.marketwatch.com 

Bernard

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To: tuck who wrote (5869)3/6/2012 4:49:55 PM
From: tuck   of 6109
 
DSCO up 35% after hours on Surfaxin approval. It would likely be more, but the company is over 6 months from launching.

Cheers, Tuck

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To: tuck who wrote (5918)3/6/2012 5:07:49 PM
From: Biotech Jim   of 6109
 
Wow, what a saga. Many a disappointed investors for DSCO from past skirmishes with the fda. Unbelievable. I guess I was the incompentent one on DSCO.

I do recall rkrw saying that the market for Surfaxin seemed overstated, especially so today?

Good luck to the patients and congrats to DSCO.

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To: Biotech Jim who wrote (5919)3/6/2012 5:23:34 PM
From: tuck   of 6109
 
I get a market of 43,000 cases/year before label restrictions.

http:///

Cheers, Tuck

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From: manny t3/7/2012 10:06:39 AM
   of 6109
 
IBIO,

Up 17.9% to 1.05.

This is the most recent patent news;

Patent Issued on Fusion-Protein Vaccine Technology
Print
Alert
Ibio Common Stock (AMEX:IBIO)
Intraday Stock Chart

Today : Wednesday 29 February 2012
Click Here for more Ibio Common Stock Charts.

iBio, Inc. (NYSE AMEX: IBIO) today announced issuance of a US patent covering the use of iBio's proprietary fusion-protein technology in combination with influenza virus antigens for vaccine product applications. The invention comprises the use of lichenase in an adjuvant-like role to improve the performance of vaccines. This approach was developed by the Fraunhofer USA Center for Molecular Biotechnology (FhCMB), iBio's research collaborator. The new patent is US Patent 8,124,103, entitled "Influenza Antigen, Vaccine Compositions, and Related Methods".

The vaccine industry is increasingly focused on the development of subunit vaccines. These subunit vaccines require use of components called adjuvants for improving their efficacy. Lichenase, when fused to antigens acts as an adjuvant and can improve the efficacy of vaccines. Fusion of lichenase to vaccine antigens can enhance duration of immune response, improve production economies and increase product stability. This approach could provide significant advantages over more conventional methodologies used to improve vaccine efficacy.

"We consider the issuance of this patent to be an important step in the expansion of opportunities in subunit vaccine development," said Vidadi Yusibov, Ph.D., one of the patent's inventors and Executive Director of FhCMB. "We previously published data demonstrating significant improvement in candidate vaccine performance in animal models when lichenase technology is employed with a range of target antigens, including antigens from plague, malaria, and human papilloma virus."

"While iBio's principal focus has been to optimize and commercialize our proprietary platform technology for broad commercial applications across the biologics field, we also have been bringing forward lichenase as a separate proprietary product platform to be licensed to enhance vaccine performance," said Robert B. Kay, Executive Chairman and CEO of iBio. "Based upon the results obtained in multiple animal studies and the formulation advantages of using a fusion protein, we believe there will be substantial commercial interest in lichenase as a proprietary approach for potent subunit vaccines."

This patent is an important addition to iBio's broader intellectual property portfolio that includes the clinical-stage iBioLaunch™ platform for vaccines and therapeutic products.

About iBio, Inc.

iBio develops and offers product applications of its iBioLaunch™ platform, providing collaborators full support for turn-key implementation of its technology for both proprietary and biosimilar products. The iBioLaunch platform is a proprietary, transformative technology for development and production of vaccines and therapeutic proteins using transient gene expression in green plants. The technology has been applied successfully to proteins difficult or impossible to produce with other methods, as well as proteins representative most important classes of biologic pharmaceuticals. Advantages of the iBioLaunch platform over other systems include enablement of rapid development and validation of modular, scalable, and optionally robotic, multi-product manufacturing facilities; production time measured in weeks instead of months or more; product entry that is unconstrained by traditional process patents; and significantly lower capital and operating costs for comparable production. Further information is available at: www.ibioinc.com.

About Fraunhofer USA Center for Molecular Biotechnology

Fraunhofer USA CMB, a division of Fraunhofer USA, Inc., is a not-for-profit research organization whose mission is to develop safe and effective vaccines targeting infectious diseases and autoimmune disorders. The Center conducts research in the area of plant biotechnology, utilizing new, cutting edge technologies to assist with the diagnosis, prevention and treatment of human and animal diseases. The Center houses individuals with expertise and excellence in plant virology, pathology, molecular biology, immunology, vaccinology, protein engineering, and biochemistry. Further information is available at www.fraunhofer-cmb.org.

Forward-Looking Statements

Statements included in this news release related to iBio, Inc. may constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements involve a number of risks and uncertainties such as competitive factors, technological development, market demand, and the Company's ability to obtain new contracts and accurately estimate net revenues due to variability in size, scope and duration of projects. Further information on potential risk factors that could affect the Company's financial results can be found in the company's Reports filed with the Securities and Exchange Commission.



Contacts:









Corporate:


Investor:






Robert Erwin, President


Douglas Beck, CFO

iBio, Inc.


iBio, Inc.

302-355-2335


302-355-9452

rerwin@ibioinc.com


ir@ibioinc.com

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To: manny t who wrote (5921)3/7/2012 2:45:55 PM
From: Jibacoa   of 6109
 
ACRX is up 25.40% on low volume, but > 3x its ADV.<g>
The stock opened with a small UG, which has not been closed.
bigcharts.marketwatch.com 

ACRX reported that it has started the PIII for ARX-01, the Sufentanil NanoTab PCA System, its "novel sublingual patient-controlled analgesia system." <g>

Bernard

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