Biotech / Medical | InterMune (nasdaq)ITMN


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To: Biomaven who wrote (491)5/21/2012 1:12:16 PM
From: ghmm   of 500
 
I found the imbalance in acute exacerbation very interesting especially given no meaningful difference in FVC. I would suspect this led to the mortal imbalance as well (but I didn't see it mentioned in the paper). I wonder if azathioprine and/or prednisone triggered this in some patients. I've seen theories on these drugs being beneficial in some patients and yet harmful in others (if there are really different underlying diseases that would make a lot of sense).

The NAC arm is continuing and past studies with NAC have shown some promise. I'd still like to see ITMN do some combo trials perhaps a small investigator trial would be a cheap/low risk way to do this. I believe they mentioned in Germany some are already trying this.

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To: ghmm who wrote (492)5/21/2012 3:26:09 PM
From: Biomaven   of 500
 
I don't think it's all that surprising that if you immune-suppress old patients with already compromised lung function you are going to run into issues with infections that would likely show up as exacerbations.

It's a bit frustrating that they don't show cause of death in these studies.

Peter

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From: tnsaf5/22/2012 12:44:36 AM
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Title: InterMune to Divest Actimmune® (Interferon Gamma-1b)

Date(s): 5/21/12 4:51 PM

For a complete listing of our news releases, please click her

-- To divest Actimmune for $55 million in cash plus a two-year royalty stream --

-- Transaction provides additional financial flexibility --

BRISBANE, Calif., May 21, 2012 /PRNewswire/ -- InterMune, Inc. (NASDAQ: ITMN) today announced that it has reached a definitive agreement with Vidara Therapeutics International Limited (Vidara) to sell its rights to Actimmune® (interferon gamma-1b) in a cash transaction valued at $55 million plus a two-year royalty stream. Vidara is part of an international specialty pharmaceutical group of companies with operations in Ireland and the United States.

Dan Welch, Chairman, Chief Executive Officer and President of InterMune said, "Several years ago, we stopped investigating new uses for Actimmune and it became a tactical financial asset for InterMune. The divesture of Actimmune will provide additional capital for InterMune to continue to focus on and invest in the registration and commercialization of Esbriet® (pirfenidone) in Europe and elsewhere and to continue to advance our R&D programs. The cash infusion from this transaction combined with $377.2 million of existing cash and cash equivalents at the end of Q1 2012 will provide additional financial resources to execute our Vision 2015 strategic plan.

The transaction with Vidara is expected to close during the second quarter of 2012, subject to satisfaction of certain closing conditions. Locust Walk Partners LLC is acting as exclusive financial advisor to InterMune in connection with the transaction.

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From: ghmm6/1/2012 11:49:30 PM
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Bosentan in IPF results are posted at clinicaltrials.gov. I am impressed with the level of information given (not the results) haven't noticed this much detail in other study results.

http://clinicaltrials.gov/ct2/show/results/NCT00391443

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From: ghmm6/1/2012 11:53:35 PM
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The other day Ian Estepan ? @ianestepan tweeted that IMS data showed 2 - 2.3 million sales for April. I have no idea on the accuracy of the information. I was under the impression IMS data wouldn't be available in Germany because of privacy laws there.

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From: ghmm6/3/2012 6:56:21 PM
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Interesting article on Pirfenidone. Granted its a meta-analysis but should help support the case for use of Pirfenidone. I am pretty sure InterMune knew about this for some time as Dan Welch was asked once to quantify the benefit of Pirfenidone and I vaguely recall the 30% figure.

err.ersjournals.com 

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To: ghmm who wrote (496)7/5/2012 2:12:13 PM
From: ghmm   of 500
 

Ian Estepan ?@ianestepan
$ITMN May IMS data for Germany released:16% mo/mo growth. 13-19% growth required to hit $7.84M cons - so #'s seem achievable...

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From: ghmm12/1/2012 6:54:11 AM
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Very Interesting study of Pirfenidone. I recall a very early pilot study that tested a much higher dose (I believe 3600mg) that was actually in more severe patient that had some signs of efficacy (it was a very small uncontrolled study so hard to draw firm conclusion). I don't recall a study dosed on weight before.

clinicaltrials.gov 

EDIT: OK this is the original early access program so not news!

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From: Biotech Jim12/12/2012 8:53:03 AM
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In the FWIW column, the Baker Bros. Hedge Fund picked up a significant stake in ITMN as of their last SEC filing. Total shares held: 868,181.

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