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 Biotech / Medical | VICL (Vical Labs)


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To: Tagore who wrote (1167)12/23/1999 6:14:00 PM
From: Scott H. Davis   of 1971
 
Don't know anything about any HSGI deal, but I do know this stock just hit an all time high. I really like this company - continued progress, straight stuff from mgmt, everything we know about publically continues to move along - just wish the vaccines were moving faster, but VICL can't control it's partner's progress/priorities.

Don't remember reading this before the recent release <<
In addition, the treatment may trigger an immune response against additional tumor cells, both locally and systemically, by enabling the immune system to recognize
other features of the tumor cells.>>

Also liked this from the release. <<The open-label, multi-center, randomized, controlled Phase III trial is designed to determine the efficacy of Allovectin-7 when combined with standard
chemotherapy in patients with unresectable, metastatic melanoma not previously treated with chemotherapy. In prior trials, Allovectin-7 was used only after standard
therapies had failed. In the new trial, patients may be enrolled upon diagnosis or upon progression to Stage III or Stage IV disease when surgery or radiation therapy
are usually no longer curative. Because Allovectin-7 is intended to trigger an immune response against tumor cells, the company believes the treatment may be more
effective in patients whose immune systems have not been compromised. >>

Still my favorite biotech. IMSCO Scott

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To: billkirn who wrote (1169)12/27/1999 11:24:00 AM
From: Scott H. Davis   of 1971
 
Bill, as a biotech investor, I'd appreciate your perspective on this. I've remarked several times in the past on this thread and others that I'm more confidant about VICL than any other developmental stage company I follow due to not only the wealth of major partners, but escecially since they have not had any clinical setbacks since I've followed. Once a med enters trials, or a partnership is established, it progresses, often slower than we'd like on the preventative technology licenses front, but nothing is cancelled.

Learned the significance with ISIP this year. Two partners ended agreements - ISIP presented great rationale, looked like things were on track, then they cancel a PIII after additional data contradicted the interim results. Tanked prime time.

Strong vol for a holiday period, another new high. Glad I held. Looks like the market is finally granting some respect. IMSCO Scott

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To: Scott H. Davis who wrote (1173)12/27/1999 5:32:00 PM
From: Jim Roof   of 1971
 
Hi Scott,

I have held for about 3 years myself and all reason and logic says to hold on for years to come. Of course, there were many days when reason and logic were not applicable to the markets and doubtless that many such days lie ahead as well. I think that VICL was technically weak for a protracted period of time after the hype it received some years back as 'the next MSFT'. I think the traders have had their fun and must either look elsewhere for their rolling action or hold and enjoy.

Jim

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To: Jim Roof who wrote (1174)12/28/1999 5:28:00 PM
From: Ron Endres   of 1971
 
29 - WOW

I felt compelled to post after three years of watching VICL meander in the teens.

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To: Ron Endres who wrote (1175)12/28/1999 7:03:00 PM
From: Phil Placier   of 1971
 
29 close is cause for celebration. I bought VICAL and ISIS at the same time about three years ago. Until ISIP plunged last month I had seriously believed that Vical was the better of the two. It is humbling to acknowledge how little I know.

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To: Phil Placier who wrote (1176)12/28/1999 7:24:00 PM
From: Scott H. Davis   of 1971
 
Blessed are the patient 4 their stock shalt rock. Seriously, I'm a lousy trader/timer. Usually buy way to far in advance. But I bought VICL at 13+ winter 97 after months of following, added more at 11+ later (should have really added around 7+ but I was having a crisis in confidence) Bought TTP at 4 1/2, saw it dip under 2, bought PTIX at 16, added more at 11+, it's now 17+ post split, bought ADIC at 16, watched it drop to 6+, now it's 51 post split, PERL at an average of about 2 1/4, saw it languish a long time, it's now 10 1/4 (took 1/2 off the table when it was in the 20's)

It'm not trying to say yeah Scott, cause I screwed up PRIME TIME earlier with OTC's (actually lost money in 96 and 97)

But I've learned to do some good DD and to keep to industries I knew something about.

So I hold when I'm convinced that the fundimentals & market are in place or improving in the face of market cluelesness (and have learned to close out when the business case changes)

Big congrads & thanks to Bill S, Pseudu, MZ and others who answered my earlier questions in 96, reassuring me to jump in.

The water was warm (deap below the surface)

Normally my investment discipline calls for taking 1/2 half off the table on a double, but my gut said that while VICL was moderately overbought, since it was making all time highs on strong volume during light volume days, coupled with a nice white marubozu yesterday that there was more upside. Glad my patientence persisted. FYI & IMSCO Scott

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To: Scott H. Davis who wrote (1177)12/28/1999 10:10:00 PM
From: William Strop   of 1971
 
Scott,

I talked to Alan Engbring when we were at around 22, before the drop to 18 & now the subsequent advance. His thoughts were that possibly everyone who wanted to sell did so in July/99 with the 4 million share day. This left the long term dregs like us.

Also that there was certainly someone(s) accumulating (as can be seen at the end of most trading days). They may have to file a 'xx-y' if they have accumulated enough.

What I think, fwiw, is that over the years Vical has made steady, consistent, usually slow progress for Vical the Company while Vical the stock traded from 7-16. The 'progress' that was being made was never reflected in the stock price. Just maybe that reflection is starting to happen.

And if I jinx the rally by saying that -- sorry. But I have always believed since 3/94 (and still believe) that they have great promise and if they continue to 'deliver' on their many pipelines the stock price will certainly appreciate.

Glad to hear you got a double...

Bill




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To: Scott H. Davis who wrote (1177)12/28/1999 10:27:00 PM
From: William Strop   of 1971
 
Scott,

Here is a post from 20 months ago mentioning patience...

*** Start ***

To: Scott H. Davis who wrote (686)
From: William Strop
Sunday, May 3, 1998 10:38 PM ET


Scott,

I agree that Vical is still a good investment. I've made it through three years & hopefully the next three will show the value of patience.

I looked back over my 2 investment notebooks on Vical this rainy afternoon to remind myself why I bought it.

The old articles dating back to 1993 all tout the value of the naked DNA vaccines. I don't think that that has ever changed. It is just the amazing span of time that is necessary to go from discovery to distribution that is worthy of being reminded of.

So doing that, I was duly reminded and will wait for at least another 3-5 years as long as we have continual clinical success.

Bill

*** End ***

Do you think this move is rooted by past performance or by anticipated events?


b

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To: William Strop who wrote (1179)12/28/1999 11:37:00 PM
From: Scott H. Davis   of 1971
 
Seeing several things, a strong biotech/healthcare day with strong institutional accumulation (look at the healthcare industry group & biotech sector),

thomsoninvest.net 

thomsoninvest.net 

the likelyhood of continued progress on malaria, the Allovectin news, with the implications of the PIII on patients who had not had prior chemo (in my opinion/hope?) means a good shot a first line therapy approval if successfull

So perhaps it's a collective judgement that VICL has made enough progress on multiple fronts that the risk/reward picture is better.

One thing for sure, if they can sell 2.5 m shares at near these prices, with their burn management and periodic licensing deals & milestones, looks like they have enough cash to complete some projects.

Not seeing any analyst upgrades/new coverage tho.

IMSCO Scott

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To: William Strop who wrote (1179)12/28/1999 11:46:00 PM
From: Scott H. Davis   of 1971
 
I'll be checking YAHOO board (I gave up on it for ISIP, was almost hype - I'll see if this is worthwhile - a LOT more posts there on VICL
messages.yahoo.com 

Check out this Bloomberg snipet

messages.yahoo.com 

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