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From: Savant8/5/2017 6:38:38 PM
   of 1179
 
genetics>>> The Age of Remodeled Humanoids...Is Upon US>>>>
popularmechanics.com


Scientists Edit Genes of 167 Embryos, the First Such Procedure on Humans in the U.S.The first CRISPR-Cas9 trial on embryos in the United States was by far the biggest trial with the gene-editing tool to edit humans.

The era of CRISPR for humans has begun.

Last week, genetic biologist Shoukhrat Mitalipov and a team of researchers at Oregon Health and Science University (OHSU) successfully edited the genes of 167 human embryos using the medical tool CRISPR-Cas9. According to a report of the study published today in Nature, they targeted a gene in the embryos called MYBPC3 to remove a mutation that can cause a common hereditary heart condition known as hypertrophic cardiomyopathy, which can result in fatal cardiac arrest even in young people and athl



The procedure was conducted on embryos created in the lab for the purpose of testing the CRISPR-Cas9 treatment. The researchers said the method was more successful than anticipated, and that using CRISPR-Cas9 to remove the target mutation should be considered for clinical trials—which would mean implanting the embryos into a mother's womb so the child is born with the genetic alterations.

"With this particular mutation, we've already done the groundwork, so we're probably much closer to clinical applications," Mitalipov said during a press call, according to MIT Technology Review. "Clinical trials would mean actually implanting some of these embryos with the goal of establishing pregnancy and monitoring births of children and hopefully following up with children."




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CRISPR stands for clustered regularly interspaced short palindromic repeats. These are segments of DNA and RNA that work with the Cas9 protein to delete and sometimes replace parts of an organism's genome. The process works in three steps. First a segment of RNA is coded with instructions to locate a specific part of the genome by copying that genetic sequence. Then the Cas9 enzyme cuts out that part of the genetic code. As an optional third step, a new DNA segment can be inserted to replace the deleted part of the genome.









In the case of the recent trial at Oregon Health and Science University, researchers deleted a part of the genome that causes a mutation that can lead to hypertrophic cardiomyopathy and filled the gap with a healthy strand of DNA. The embryos were created from eggs donated by healthy women, which were artificially inseminated with sperm from males carrying the mutation. While Chinese researchers have conducted three CRISPR trials on human embryos, the OHSU study was by far the largest procedure with the most embryos modified.

The procedure was most effective when CRISPR-Cas9 was injected into the eggs along with the sperm rather than immediately after. In this case, 42 out of the 58 edited embryos were free of the mutation that causes hypertrophic cardiomyopathy. Under normal circumstances, 50 percent of eggs fertilized by a father carrying the cardiomyopathy mutation will also carry the genetic flaw. Using CRISPR improved that ratio so only about 28 percent received the mutation, and 72 percent became healthy embryos.

However, the 16 embryos that did not become free of the mutation experienced unintended genetic deletions or insertions. This margin of error shows that the CRISPR-Cas9 tool is not perfect, and improvements are still needed.

Proponents of this procedure point out that fathers who carry the mutation can take advantage of such treatments to completely delete the dangerous genetic flaw from the family lineage. Opponents argue that parents can already used established medical processes, such as in vitro fertilization (IVF) and genetic scans, to fertilize eggs in the lab and only implant healthy eggs back into the mother's womb. However, the team that conducted the recent study argues that CRISPR can be used to augment this process and increase the probability of pregnancy.

More importantly, CRISPR-Cas9 has the potential to prevent a myriad of diseases and conditions beyond hypertrophic cardiomyopathy, which affects about 1 in 500 people. Gene editing procedures could also treat patients with sickle cell anemia, HIV, and multiple types of cancers including leukemia and breast cancer. Treating these conditions at an early age, or even before the patient is born, could also result in huge cost savings for the medical industry—the ultimate preventative care.

But there is no shortage of concerns regarding genome editing. Some opponents argue the unforeseen effects present a real danger in these types of procedures, and others worry that disease treatment with gene editing is the first step toward a future of so-called "designer babies."

The regulation of future CRISPR research in the United States remains unclear as well. While genome editing studies are permitted in specific circumstances, such as the OHSU study, clinical trials are still forbade by Congress. In addition, the National Institutes of Health does not fund research on human embryos, which is where CRISPR is most effective at preventing disease. Given these barriers, it is possible U.S. researchers look to other countries to continue their work.

"There is a long road ahead, particularly if you want to do this study in a regulated way," said Mitalipov. "It's unclear at this point when we would be able to move on. We would be supportive to moving this technology to other countries."

Doctors and medical researchers have demonstrated that genome modification can be highly effective at treating and preventing otherwise lethal and permanent human diseases. CRISPR will almost certainly become more commonly used in the future, as institutions around the world prepare to conduct studies of their own. Whether CRISPR is a miracle procedure, humanity's tool to ensuring good health, or if it could cause unforeseen physical and societal consequences, is yet to be seen.

Source: MIT Technology Review

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From: Savant8/7/2017 4:16:57 PM
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It's dynamite...TNT Tissue NanoTransfection

A new device developed at The Ohio State University can start healing organs in a "fraction of a second," researchers say.

The technology, known as Tissue Nanotransfection (TNT), has the potential to save the lives of car crash victims and even deployed soldiers injured on site. It's a dime-sized silicone chip that "injects genetic code into skin cells, turning those skin cells into other types of cells required for treating diseased conditions," according to a release.

In lab tests, one touch of TNT completely repaired injured legs of mice over three weeks by turning skin cells into vascular cells.

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From: Savant8/16/2017 9:38:00 PM
   of 1179
 

Alternate Fuels/Biofuel/ recycled Fatbergs>>>


*A better solution would be to somehow capture the fats and oils before they hit the sewers...Recycling R US
As a kid, we saved the cooking grease in a metal coffee can...for use later, or put it into the garbage can
By Y10K, they'll HAVE to recycle it...or else!




http://news.nationalgeographic.com/2017/08/fatbergs-fat-cities-sewers-wet-wipes-science/





snip>>
In the United States, many cities eventually required restaurants and other food sellers to have grease traps and to clean them out, and a surprising amount of controversy and intrigue has grown around these caches of fat. In some places, thieves blowtorch their way into grease traps to steal used cooking oil that can be made into biofuels.
---
Yum>>>
In China, fat from sewers and traps is illicitly scooped, cleaned up—though not well—and sold on the black market as “ gutter oil.” In cheap restaurants and street stalls, your dinner might even be cooked in gutter oil.
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Some cities are even looking at fatbergs as legitimate fuel. After all, fat is high in calories and therefore energy. Thames Water has partnered with a renewable-fuel company to dig fatbergs out of sewers and turn them into biodiesel.
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From: Savant8/17/2017 12:57:08 PM
   of 1179
 

Spiders spinning bionic silk, incorporating graphene.....

msn.com

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From: Savant8/17/2017 2:42:51 PM
   of 1179
 

Xenotransplantation retroviral free pigs & Pig 2.0

msn.com


eGenesis

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To: Savant who wrote (1156)8/17/2017 2:50:55 PM
From: Savant
   of 1179
 
Beyond Y10K..... The way our world/Universe will end
msn.com

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To: Savant who wrote (1157)8/17/2017 3:03:05 PM
From: Savant
   of 1179
 

Rare films of nuclear bomb tests...digitized for study.

Note the number of ships surrounding the blast, about 2 min into the video....hope no one was aboard

msn.com

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From: Savant8/25/2017 11:37:14 AM
   of 1179
 
Nanotubule yarn, generates electricity when stretched...v.efficient in re:output vs weight

arstechnica.com

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From: Savant8/28/2017 7:49:48 PM
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Quantum messaging in seawater...possibly up to 900m...& beyond
msn.com

Scientists have achieved quantum communication in sea water, showcasing a futuristic concept for 'encrypted' underwater information exchange.





In a bid to devise methods for 'unhackable' ways of underwater communication, a team of researchers from Shanghai Jiao Tong University sent information between entangled particles through sea water.




The idea of quantum (secure) communication is not new and several scientists are already working on it, but this is the first instance where information has been transposed in water. The researchers have managed to communicate across a 3.3m long tank of seawater and they say the same mechanism could also be used to send 'unhackable' messages through 900m of open sea water.

To achieve this feat, the scientists followed the concept of quantum entanglement – the idea of linking two distant particles to the point where manipulation of one particle leads to an immediate and automatic reaction from its counterpart. They utilised water's well-known capability of scattering light and a prism to create the entangled particles. Put simply, a beam of light was shot into a crystal to split into a pair linked photons, with exactly opposite polarisation.

With both particles at opposite ends of the tank, the team demonstrated that despite being distant, they were able to transpose accurate information over 98% of the time.

The possible applications of the technique are evident, with the best one being integration with submarines for secure communications. In The Optical Society, the researchers wrote: "Our results confirm the feasibility of a seawater quantum channel, representing the first step towards underwater quantum communication."

The experiment is clearly promising, but as these are nascent stages, it still remains to be seen whether scientists will be able to build on this breakthrough into a future of 'quantum communication' across greater distances.



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From: Savant8/28/2017 8:28:38 PM
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More will be found, but so far>>

25 unexplained archaeological finds...some frequently mentioned, some not so often

livescience.com

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