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From: Savant1/21/2012 1:12:24 AM
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%Donpat>> Drink Bathtubs of beer, live longer>Tiny Amounts of Alcohol Dramatically Extend a Worm's Life, but Why?

[ Serendipity!!! One beer diluted into a hundred gallons of water = super lite beer! The fountain of youth!! Ponce de Leon - vindication, finally!!!! LoL]


ScienceDaily (Jan. 20, 2012)Minuscule amounts of ethanol, the type of alcohol found in alcoholic beverages, can more than double the life span of a tiny worm known as Caenorhabditis elegans, which is used frequently as a model in aging studies, UCLA biochemists report. The scientists said they find their discovery difficult to explain.

In humans, alcohol consumption is generally harmful, Clarke said, and if the worms are given much higher concentrations of ethanol, they experience harmful neurological effects and die, other research has shown."This finding floored us -- it's shocking," said Steven Clarke, a UCLA professor of chemistry and biochemistry and the senior author of the study, published Jan. 18 in the online journal PLoS ONE, a publication of the Public Library of Science.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029984

"We used far lower levels, where it may be beneficial," said Clarke, who studies the biochemistry of aging.

The worms, which grow from an egg to an adult in just a few days, are found throughout the world in soil, where they eat bacteria. Clarke's research team -- Paola Castro, Shilpi Khare and Brian Young -- studied thousands of these worms during the first hours of their lives, while they were still in a larval stage. The worms normally live for about 15 days and can survive with nothing to eat for roughly 10 to 12 days.

"Our finding is that tinyamounts of ethanol can make them survive 20 to 40 days," Clarke said.

Initially, Clarke's laboratory intended to test the effect of cholesterol on the worms. "Cholesterol is crucial for humans," Clarke said. "We need it in our membranes, but it can be dangerous in our bloodstream."

The scientists fed the worms cholesterol, and the worms lived longer, apparently due to the cholesterol. They had dissolved the cholesterol in ethanol, often used as a solvent, which they diluted 1,000-fold.

"It's just a solvent, but it turns out the solventwas having the longevity effect," Clarke said. "The cholesterol did nothing. We found that not only does ethanol work at a 1-to-1,000 dilution, it works at a 1-to-20,000 dilution. That tiny bit shouldn't have made any difference, but it turns out it can be so beneficial."

How little ethanol is that?

"The concentrations correspond to a tablespoon of ethanol in a bathtub full of water or the alcohol in one beer diluted into a hundred gallons of water," Clarke said.

Why would such little ethanol have such an effect on longevity?

"We don't know all the answers," Clarke acknowledged. "It's possible there is a trivial explanation, but I don't think that's the case. We know that if we increase the ethanol concentration, they do not live longer. This extremely low level is the maximum that is beneficial for them."

The scientists found that when they raised the ethanol level by a factor of 80, it did not increase the life span of the worms.

The research raises, but does not answer, the question of whether tiny amounts of ethanol can be helpful for human health. Whether this mechanism has something in common with findings that moderate alcohol consumption in humans may have a cardiovascular health benefit is unknown, but Clarke said the possibilities are intriguing.

In follow-up research, Clarke's laboratory is trying to identify the mechanism that extends the worms' life span.

About half the genes in the worms have human counterparts, Clarke said, so if the researchers can identify a gene that extends the life of the worm, that may have implications for human aging.

"It is important for other scientists to know that such a low concentration of the widely used solvent ethanol can have such a big effect in C. elegans," said lead author Paola Castro, who conducted the research as an undergraduate in Clarke's laboratory before earning a bachelor's degree in biochemistry from UCLA in 2010 and joining the Ph.D. program in bioengineering at UC Santa Cruz. "What is even more interesting is the fact that the worms are in a stressed developmental stage. At high magnifications under the microscope, it was amazing to see how the worms given a little ethanol looked significantly more robust than worms not given ethanol."

"While the physiological effects of high alcohol consumption have been established to be detrimental in humans, current research shows that low to moderate alcohol consumption, equivalent to one or two glasses of wine or beer a day, results in a reduction in cardiovascular disease and increased longevity," said co-author Shilpi Khare, a former Ph.D. student in UCLA's biochemistry and molecular biology program who is now a postdoctoral fellow at the Genomics Institute of the Novartis Research Foundation in San Diego. "While these benefits are fascinating, our understanding of the underlying biochemistry involved in these processes remains in its infancy.

"We show that very low doses of ethanol can be a worm 'lifesaver' under starvation stress conditions," Khare added. "While the mechanism of action is still not clearly understood, our evidence indicates that these 1 millimeter-long roundworms could be utilizing ethanol directly as a precursor for biosynthesis of high-energy metabolic intermediates or indirectly as a signal to extend life span. These findings could potentially aid researchers in determining how human physiology is altered to induce cardio-protective and other beneficial effects in response to low alcohol consumption."

Clarke's laboratory identified the first protein-repair enzyme in the early 1980s, and his research has shown that repairing proteins is important to cells. In the current study, the biochemists reported that life span is significantly reduced under stress conditions in larval worms that lack this repair enzyme. (More than 150 enzymes are involved in repairing DNA damage, and about a dozen protein-repair enzymes have been identified.)

"Our molecules live for only weeks or months," Clarke said. "If we want to live long lives, we have to outlive our molecules. The way we do that is with enzymes that repair our DNA -- and with proteins, a combination of replacement and repair."

Researcher Brian Young, now an M.D./Ph.D. student at the David Geffen School of Medicine at UCLA, is a co-author on the research.

The research was federally funded by the National Institutes of Health's National Institute of General Medical Sciences.

http://www.sciencedaily.com/releases/2012/01/120120184540.htm

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From: TimF2/2/2012 5:55:41 PM
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coyoteblog.com

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From: TimF2/11/2012 7:28:24 PM
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ghostgrey.gaetanmarie.com

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From: Glenn Petersen2/19/2012 11:40:28 AM
2 Recommendations   of 3488
 
No Bitter Aftertaste From This Stock Offering

By JEFF SOMMER
New York Times
February n18, 2012

JIM KOCH is well known among beer aficionados for creating the full-bodied brew called Samuel Adams Boston Lager and for helping to foster the craft brew movement in the United States.

He is less well known for playing an important role in another niche revolution — one that has the potential to be at least as significant.

What could be better for the quality of life in America than good beer? That’s a high hurdle, I’m the first to admit, but bear with me.

Consider that in 1995, when it was time to take the Boston Beer Company public, Mr. Koch moved his loyal customers to the front of the line, and made sure that they could buy shares at the most favorable price. He wanted to help beer guys, not Wall Street guys. He did this not as a philanthropist but as a die-hard capitalist, believing that his fledgling beer company would be better off in the long run if he democratized its initial public offering.

“It’s good for a company if its shares are in the hands of the people who really believe in it — and for us that means the people who really love Sam Adams beer,” he said in a telephone interview.

Unlike the founders of many consumer-oriented companies that are ready for initial public offerings — Facebook is a prominent current example — Mr. Koch decided that his I.P.O. would be consumer-oriented. A graduate of Harvard and of the Boston Consulting Group — and a dropout from a joint Harvard business-law graduate program in which Mitt Romney was a classmate — he examined how traditional I.P.O.’s actually worked. He concluded that he could do better if he harnessed the same innovative energy that he used to build his business.

As Mr. Koch saw it, when an I.P.O. is controlled by investment banks, it is structured “to reward the banks and their favored institutional investors” and not the fledgling business or its customers. He realized that he “wasn’t comfortable letting Wall Street underwriters control the process, set the price and allocate the shares to their favored clients at a favorable price.”

Instead, he said: “I wanted to take care of my Sam Adams drinkers. They were the people who were really important to me and who were going to continue to be.”

So he improvised, hanging fliers on six-packs of beer that very carefully informed customers that they might be able to buy $500 worth of shares in an eventual public offering. “We were limited to what you could manage to say on a six-pack, and also by what the lawyers would let us say,” he recalls.

“The laws and regulations were set up to make this kind of thing very difficult,” he says. “But I had a strong feeling that we should do this.”

He sold shares at two prices. Some went to his customers, who, in a startling reversal, got a better deal than Wall Street insiders: $15 a share for the customers, versus $20 for those who bought at the opening price in a public offering run by Goldman Sachs.

Mr. Koch recalls the horrified reaction of one irate fund manager. “So I’m going to buy shares for $20 while you’re selling them to these cat-and-dog investors for $15?”, the man sputtered. “I always get the lower price. You’ve turned things upside down.”

Mr. Koch says that when he asked the manager whether he drank much beer, the man replied: “Not really, I’m mostly a wine drinker.” To which Mr. Koch responded: “That proves my point. I care about beer drinkers, not wine-drinking fund managers. You don’t really matter to me.”

Securities and Exchange Commission rules required Mr. Koch to indicate in advance how many shares he would sell directly to customers, he says. He came up with an estimate of 30,000 buyers — but it was only a guess, and it turned out to be way too low. Instead, he says, more than 100,000 would-be shareholders sent in checks. He used a lottery to select 30,000, sending the rest of the checks back. “If I’d had any idea how much interest there would be, I could have sold all the shares directly to customers,” he says now. “But I just didn’t know. Nobody had done this before.”

To help sell stock directly to customers, Mr. Koch brought in a like-minded banker, William R. Hambrecht, a prominent Silicon Valley venture capitalist who was determined to improve the I.P.O. process. “I thought Jim was really onto something,” Mr. Hambrecht recalled in a telephone interview. “It got me thinking that we ought to be able to come up with a better way to do this.”

Based on that experience, Mr. Hambrecht says, he went on to develop the model for modified Dutch auction I.P.O.’s. These were made famous by Google in 2004 and adapted by Morningstar in 2005 and later by other companies. In structure, they are descending price auctions, aimed at determining the highest bid that would clear a market open to all investors and not just insiders.

Eric Schmidt, executive chairman of Google, declined to comment for this column, but he has written that despite some problems, its auction was an essential part of Google’s stated goal to “do no evil.”

In a phone interview, Joe Mansueto, founder of Morningstar, called his company’s auction-based I.P.O. “a terrific success.” He pursued it, he said, because “it just squared very nicely with the ethos of Morningstar to help investors of all stripes and not just institutional investors.”

He added that “it seemed funny to use the traditional book-building process that lets the underwriter,” who is “biased” toward its best customers, decide who gets the inside price. “Making sure that all investors have equal access to shares was the better method, the right method for us,” he said.

While there have been some ups and downs, shares in all three of these companies have proved excellent long-term investments, and their I.P.O.’s helped to reinforce the companies’ image as unusually consumer-friendly.

Most of those customer-shareholders have retained their investments in the beer company, Mr. Koch says. “It’s helped to give us stability and a lot of support,” he said. Those $15 shares are now worth more than $100 each.

Both Mr. Koch and Mr. Mansueto say they are surprised that Facebook hasn’t indicated that it will embrace a more democratic public offering, though it could still do so.

“It’s not easy to go up against Wall Street,” said Mr. Mansueto, who said his own background, as a graduate of the University of Chicago business school and founder of an investor services company, gave him the ability to do it. “Most people have I.P.O.’s only once in their life, and they tend to trust the professionals, the Wall Street bankers, the way they’d instinctively trust a dentist or a doctor,” he said. “You have to have a lot of self-confidence and a lot of expertise to go against that advice.”

Matthew Rhodes-Kropf, a professor at Harvard Business School, says I.P.O. auctions are still relatively rare because of those factors, and because they are not in the fundamental interest of most banks. “Wall Street will always hate I.P.O. auctions,” he says, “because Wall Street is all about insider access, and these auctions take it away.”

Mr. Hambrecht is still running I.P.O. auctions, even though, he says, “it’s a little like tilting at windmills.” It doesn’t matter, he says: “I believe it’s the right thing to do.”

nytimes.com

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To: Glenn Petersen who wrote (3234)2/20/2012 12:27:00 AM
From: Savant
1 Recommendation   of 3488
 
TravelZoo did one better...they gave out free shares. I received some.
They split, and ran to $100+ took a dive, and then ran higher again. TZOO
When it was hard to get an allotment of IPO stock, I suggested to Ameritrade and Etrade that they let account holders in on the deal. They did.

Sad to say, I missed seeing the Sam Adams promotion.

techdirt.com

Finished a bottle of Quelque Chose last night, 2008....yum...bottle says it's good until 2025...well, the bottle
might be, the brew is gone...lol.

Best,
S.

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To: Glenn Petersen who wrote (3234)2/20/2012 7:42:52 AM
From: ~digs
   of 3488
 
interesting, the low for the stock in 2009 was exactly half way between the $15 customer offering and the $20 institutional offering..

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To: Savant who wrote (3235)2/20/2012 10:25:40 AM
From: Glenn Petersen
   of 3488
 
Thanks for the reminder on TravelZoo. I remember the offering and have been trying to recall their name.

Message 20188633

There was at least one other Internet company that did something similar, but it may not have ended as well.

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From: TimF2/21/2012 9:00:24 PM
1 Recommendation   of 3488
 
Beer in moderation benefits health

Moderate and regular consumption of beer, like wine, can reduce the risk of cardiovascular disease, Italian researchers say.

The study conducted by Research Laboratories at the Fondazione di Ricerca e Cura "Giovanni Paolo II", in Campobasso, Italy, confirmed what was already known about wine: a moderate consumption (approximately two glasses per day for men and one for women) can lower the risk of cardiovascular disease, up to 31 per cent less when comparing to non drinkers.

What this research adds are new data on beer. For the first time, in fact, evidence about dose-dependent effect is shown for this beverage.

Maximum protection is observed, for a beer containing 5 percent of alcohol, with a consumption of slightly more than an English pint a day.

"In our research we considered wine and beer separately: you first observe a reduction in cardiovascular risk with low to moderate drinking," explained Simona Costanzo, first author of the study.

"Then, with an increasing consumption, you can see that the advantage disappears, until the risk gets higher. The interesting part of our research is that, among the studies selected for this meta-analysis, there were 12 in which wine and beer consumption could be compared directly. Using these data we were able to observe that the risk curves for the two beverages are closely overlapping," she stated...

articles.timesofindia.indiatimes.com

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From: ~digs2/25/2012 8:22:52 AM
1 Recommendation   of 3488
 
What Beer Can Teach Us About Emerging Technologies
The home-brew movement serves as a lesson in DIY innovation
slate.com

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From: JakeStraw3/9/2012 7:47:01 AM
   of 3488
 
SUNOCO BRINGS NEW MEANING TO FILL 'ER UP

Sunoco has expanded its Sunoco's Craft Beer Exchange Program from New York into South Carolina. "We have decided to expand the Craft Beer Exchange based on the success we have had in multiple New York markets over the last six months," said Wendy Lyman, Sunoco's beverage category manager. The Craft Beer Exchange allows customers to fill growlers with craft beer at the same place they fill up their gas tanks. Currently Sunoco has "beer-filling stations" (taps) at over 40 of its APlus convenience stores throughout New York state.

Sunoco operates more than 600 APlus Convenience stores in 24 states along the east coast and as far west as Ohio. The company says the program will now increase to include 13 locations across coastal South Carolina.

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