Biotech / Medical | Genstar GNT(formerly UroGen)-- an interesting speculation


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To: Paul Lee who wrote (3)7/10/1998 11:15:00 AM
From: Elliot Lepler   of 100
 
I can't believe this news has not caused more of a stir. The company has a technology that has cured prostate tumors in mice. They have a big brother in Baxter and a market cap of less than $20 million.

Should not be long before they are recognized. I noticed that the news of their deal with Baxter did not appear under that company's news.

Consider what happened to ENMD-this is a rocket waiting to be lit.

I have my position in place and will hold long term. This potential profit is enormous. My usual time frame is years, but I suspect prices under $1 will not last long.

Elliot

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To: Elliot Lepler who wrote (4)7/13/1998 3:19:00 AM
From: Jeffrey S. Mitchell   of 100
 
According to the recent press release, UROG gave Baxter the equivalent of 5,444,000 + 1,768,319 + 325,000 = 7,537,319 shares of common stock. That is obviously a ton of stock for the market to absorb for a company that trades a few thousand shares a day.

What do you think is so special about the technology Baxter gave UROG that was worth so much money and adds so much potential dilution to the share price?

- Jeff

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To: Jeffrey S. Mitchell who wrote (5)7/13/1998 9:27:00 AM
From: Elliot Lepler   of 100
 
Jeff,

You are correct that UROG has given Baxter about 7 million shares out of about 20 million that will be outstanding.

Baxter has the technology-the virus that allows infection and expression of DNA. The virus is a shell and DNA is inserted. With infection the protein coded by that DNA is produced.

First experiments were with two diseases. In hemophilia a protein called Factor VIII is defective. The DNA for the correct protein is carried in the virus. The patient is infected and for the duration of the infection-some months-the patient's cells make the viral, correct, factor VIII, naturally treating the condition.

In prostate cancer, the virus is targeted to kill cells which make PSA, prostate specific antigen. As was reported in the press release last week, the virus eliminated prostate turmors in mice.

These are very significant uses and markets. UroGen will do the development for Baxter. Without Baxter's technology and backing the company is worthless. UROG brings scientific know how. The scientists involved are those who have development the monolclonal antibody that Genentech markets agains lymphoma.

So the partnership includes the basic technology from Baxter and the expertise from UROG. The market cap at present is less than $20 million. If sucessful, the applications should generate many many times that value.

Even before, the market should be valuing them higher. The word is not out --- yet.

Elliot

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To: Elliot Lepler who wrote (6)7/13/1998 9:36:00 AM
From: Jeffrey S. Mitchell   of 100
 
Thanks for the explanation. Would you say that Baxter's vector that they now have exclusive rights to use constitutes novel technology in that it makes it that much more difficult for others to copy UROG's entire process? I'm curious how many other similar vectors you know are out there and which biotech firms have either developed them or have rights to exclusively use them. I think UROG has an exciting combination but I'd like to find out how unique it is in the industry.

Thanks!

- Jeff

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To: Jeffrey S. Mitchell who wrote (7)7/13/1998 10:10:00 AM
From: Elliot Lepler   of 100
 
Jeff,

I am not sure how unique this vector is, but it must have some significant value since the scientists involved have chosen it. I am not aware enough of competitors to give you a better answer than that.

Also Baxter must have confidence or they would not be putting up the money for an equity interest.

I invite others who may know more to comment.

Elliot

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To: Elliot Lepler who wrote (8)8/3/1998 10:10:00 PM
From: Elliot Lepler   of 100
 
This news is very significant. IDEC developed the new monoclonal antibody drug that Genentech markets for lymphoma. Dr. Sobol has a track record. The market is valuing this company at about $12 million. It should be more like 5 to 10 times that value. Undiscovered. I am loading up big time.


SAN DIEGO--(BW HealthWire)--Aug. 3, 1998--UroGen Corp. (OTCBB:UROG) announced that Robert E. Sobol, M.D. has been named president, chief executive officer and director.

Sobol replaces Paul Quadros who was named chairman of the board. Sobol, a founder of IDEC Pharmaceuticals, had previously served as UroGen's executive vice president and chief operating officer. Joining Sobol as new members of the board of directors are Victor W. Schmitt, president, Venture Management Baxter Healthcare and Wei-Wei Zhang, M.D., Ph.D., director, Molecular Biology of Baxter Healthcare's Gene Therapy Unit. Zhang leads the team of scientists joining UroGen and relocating to San Diego. Sobol, Schmitt and Zhang join Quadros, Ivor Royston, M.D. and Peter Bernardoni on the UroGen board of directors.

Commenting on Sobol's appointment Paul Quadros, chairman stated, "Dr. Sobol brings to his new role as the CEO of UroGen a rare combination of business, scientific and clinical experience needed at this point in our development. With our recent acquisition of new gene delivery technologies from Baxter, we need to rapidly move our products into the clinic. Dr. Sobol has an impressive record of bringing innovative therapy to patients."

UroGen is a biotechnology company currently developing products for the diagnosis and treatment of prostate cancer. Based on its recent corporate partner agreement with Baxter, the company's charter will now expand to include treatments for other forms of cancer and genetic disorders.

--30--lc/sd* NG/sd

CONTACT:

UroGen Corporation

Robert E. Sobol, 619/450-5949

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To: Paul Lee who wrote ()1/4/2000 7:58:00 PM
From: Elliot Lepler   of 100
 
Urogen took quite a pop today. I hear there will be significant news about financing clinical trials in the next week or so.

The company has an adenoviral vector to transfer genes to "cure" hemophilia. The potential market is in the $Billion range and the stock sells with a market cap in the $35Million range even with today's jump.

The most comparable company is AVGN Avigen which has a market cap of $360 Million. There will be more pr soon and the stock will be moving much higher.

Avigen has a therapy for hemophilia B which is much less common than hemophilia A. Also UROG has a significant corporate partner in Baxter. Avigen is looking for a partner according to their website.

You heard it here.

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To: Elliot Lepler who wrote (10)1/18/2000 6:25:00 PM
From: Elliot Lepler   of 100
 
HELLO,

Anybody there? UROG hit $3 today. Nobody but me on this board. Please leave a messge if you have read this. Thanks.

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To: Elliot Lepler who wrote (11)1/18/2000 7:30:00 PM
From: Paul Lee   of 100
 
So what, you show up for bragging rights?

Well, guess you deserve them, but can it hold this price?

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To: Elliot Lepler who wrote (11)1/19/2000 4:39:00 AM
From: Annie   of 100
 
Good morning Elliot...

I'm here--isn't that all that matters? And yes, have read this (you need to post more often)! It might wake up this thread if you do!!!

One more thing, I have no intention of selling @ $3...

BTW, what price do you see for UROG now ol' soothsayer?

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